Prediction of fruit and vegetable intake from biomarkers using individual participant data of diet-controlled intervention studies

Prediction of fruit and vegetable intake from biomarkers using individual participant data of diet-controlled intervention studies

Souverein, O.W.
de Vries, J.H.M.
Freese, R.
Watzl, B.
Bub, A.
Miller III, E.R.
Castenmiller, J.J.M.
Pasman, W.J.
van het Hof, K.
Chopra, M.
Karlsen, A.
Dragsted, L.O.
Winkels, R.
Itsiopoulos, C.
Brazionis, L.
O'Dea, K.
van Loo-Bouwman, C.A.
Naber, T.H.J.
van der Voet, H.
Boshuizen, H.C.

2015

Fruit and vegetable consumption produces changes in several biomarkers in blood. The present study aimed to examine the dose-response curve between fruit and vegetable consumption and carotenoid (α-carotene, β-carotene, β-cryptoxanthin, lycopene, lutein and zeaxanthin), folate and vitamin C concentrations. Furthermore, a prediction model of fruit and vegetable intake based on these biomarkers and subject characteristics (i.e. age, sex, BMI and smoking status) was established. Data from twelve diet-controlled intervention studies were obtained to develop a prediction model for fruit and vegetable intake (including and excluding fruit and vegetable juices). The study population in the present individual participant data meta-analysis consisted of 526 men and women. Carotenoid, folate and vitamin C concentrations showed a positive relationship with fruit and vegetable intake. Measures of performance for the prediction model were calculated using cross-validation. For the prediction model of fruit, vegetable and juice intake, the root mean squared error (RMSE) was 258.0 g, the correlation between observed and predicted intake was 0.78 and the mean difference between observed and predicted intake was -1.7 g (limits of agreement: -466.3, 462.8 g). For the prediction of fruit and vegetable intake (excluding juices), the RMSE was 201.1 g, the correlation was 0.65 and the mean bias was 2.4 g (limits of agreement: -368.2, 373.0 g). The prediction models which include the biomarkers and subject characteristics may be used to estimate average intake at the group level and to investigate the ranking of individuals with regard to their intake of fruit and vegetables when validating questionnaires that measure intake. Copyright © The Authors 2015.

Life
MSB - Microbiology and Systems Biology
ELSS - Earth, Life and Social Sciences
Biomedical Innovation
Health
Healthy Living
Carotenoids
Folate
Fruits and vegetables
Prediction models
Vitamin C
Ascorbic acid
Beta carotene
Beta cryptoxanthin
Biological marker
Folic acid
Lycopene
Xanthophyll
Zeaxanthin
Age distribution
Body mass
Food intake
Fruit juice
Fruitarian diet
Prediction
Questionnaire
Sex difference
Smoking
Validation process
Vegetarian diet
Vitamin blood level

http://resolver.tudelft.nl/uuid:f5794628-863a-4340-b040-9737fb906035

https://doi.org/10.1017/s0007114515000355

526107

0007-1145

British Journal of Nutrition, 113 (9), 1396-1409

article