Oral glucose intake inhibits hypothalamic neuronal activity more effectively than glucose infusion

Oral glucose intake inhibits hypothalamic neuronal activity more effectively than glucose infusion

Smeets, P.A.M.
Vidarsdottir, S.
de Graaf, C.
Stafleu, A.
van Osch, M.J.P.
Viergever, M.A.
Pijl, H.
van der Grond, J.
TNO Kwaliteit van Leven

2007

We previously showed that hypothalamic neuronal activity, as measured by the blood oxygen level-dependent (BOLD) functional MRI signal, declines in response to oral glucose intake. To further explore the mechanism driving changes in hypothalamic neuronal activity in response to an oral glucose load, we here compare hypothalamic BOLD signal changes subsequent to an oral vs. an intravenous (iv) glucose challenge in healthy humans. Seven healthy, normal-weight men received four interventions in random order after an overnight fast: 1) ingestion of glucose solution (75 g in 300 ml) or 2) water (300 ml), and 3) iv infusion of 40% glucose solution (0.5 g/kg body wt, maximum 35 g) or 4) infusion of saline (0.9% NaCl, equal volume). The BOLD signal was recorded as of 8 min prior to intervention (baseline) until 30 min after. Glucose infusion was associated with a modest and transient signal decline in the hypothalamus. In contrast, glucose ingestion was followed by a profound and persistent signal decrease despite the fact that plasma glucose levels were almost threefold lower than in response to iv administration. Accordingly, glucose ingestion tended to suppress hunger more than iv infusion (P < 0.1). We infer that neural and endocrine signals emanating from the gastrointestinal tract are critical for the hypothalamic response to nutrient ingestion. Copyright © 2007 the American Physiological Society.

Biology
Food and Chemical Risk Analysis
Functional magnetic resonance imaging
Glucose homeostasis
Incretins
Insulin
gastrointestinal polypeptide
glucose
adult
article
controlled study
glucose blood level
glucose infusion
human
hunger
hypothalamus
insulin release
male
nerve cell
nerve conduction
normal human
nuclear magnetic resonance imaging
oral glucose tolerance test
oxygen blood level
priority journal
Action Potentials
Administration, Oral
Adult
Dose-Response Relationship, Drug
Glucose
Humans
Hypothalamus
Infusions, Intravenous
Male
Neural Inhibition
Neurons

http://resolver.tudelft.nl/uuid:f4e06f08-92ed-4bd0-a3ef-58487d01e854

https://doi.org/10.1152/ajpendo.00231.2007

240154

0193-1849

American Journal of Physiology - Endocrinology and Metabolism, 293 (3)

article