Title
Re-evaluation of the haptoglobin reference values with the radial immunodiffusion technique
Author
Instituut CIVO-Toxicologie en Voeding TNO
Schrijver, J.
van Rijn, H.J.M.
Schreurs, W.H.P.
Publication year
1984
Abstract
The reference values of the three main types of serum haptoglobin Hp 1-1, Hp 2-1, and Hp 2-2, as determined by radial immunodiffusion and with phenotype determination on polyacrylamide gel electrophoresis have been re-evaluated for both sexes. For that purpose about 500 serum samples were collected from normal, healthy Dutch volunteers. The relative occurrence of the three main types of serum haptoglobin in Dutch men and women was found to be comparable to that reported for other whites, with Hp 2-1 phenotype predominating in the Dutch population and phenotype Hp 0-0 being absent. The observed overall reference range of haptoglobin for the Dutch population, irrespective of the phenotype, was 0.50-3.30 g/L serum. As reported by other investigations we found that the reference values for the three main types of haptoglobin significantly differed (Hp 1-1: 1.40 ?? 0.51; Hp 2-1: 2.10 ?? 0.76; and Hp 2-2: 1.65 ?? 0.73 g/L serum, mean ?? SD). However, in contrast to the data available in the literature, the reference values of haptoglobin for men and for women, as determined by the radial immunodiffusion technique, were not significantly different. Chemicals/CAS: haptoglobin, 9087-69-8; Haptoglobins.
Subject
Haptoglobin
Diagnosis
Human
Standard
Adolescent
Adult
Aged
Blood Protein Electrophoresis
Caucasoid Race
Electrophoresis, Polyacrylamide Gel
Haptoglobins
Human
Immunodiffusion
Male
Middle Age
Netherlands
Phenotype
Reference Values
Sex Factors
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TNO identifier
229544
ISSN
0009-9120
Source
Clinical Biochemistry, 17 (17), 258-262
Document type
article