Print Email Facebook Twitter Tissue distribution of quercetin in rats and pigs Title Tissue distribution of quercetin in rats and pigs Author de Boer, V.C.J. Dihal, A.A. van der Woude, H. Arts, I.C.W. Wolffram, S. Alink, G.M. Rietjens, I.M.C.M. Keijer, J. Hollman, P.C.H. TNO Kwaliteit van Leven Publication year 2005 Abstract Quercetin is a dietary polyphenolic compound with potentially beneficial effects on health. Claims that quercetin has biological effects are based mainly on in vitro studies with quercetin aglycone. However, quercetin is rapidly metabolized, and we have little knowledge of its availability to tissues. To assess the long-term tissue distribution of quercetin, 2 groups of rats were given a 0.1 or 1% quercetin diet [∼50 or 500 mg/kg body weight (wt)] for 11 wk. In addition, a 3-d study was done with pigs fed a diet containing 500 mg quercetin/kg body wt. Tissue concentrations of quercetin and quercetin metabolites were analyzed with an optimized extraction method. Quercetin and quercetin metabolites were widely distributed in rat tissues, with the highest concentrations in lungs (3.98 and 15.3 nmol/g tissue for the 0.1 and 1% quercetin diet, respectively) and the lowest in brain, white fat, and spleen. In the short-term pig study, liver (5.87 nmol/g tissue) and kidney (2.51 nmol/g tissue) contained high concentrations of quercetin and quercetin metabolites, whereas brain, heart, and spleen had low concentrations. These studies have for the first time identified target tissues of quercetin, which may help to understand its mechanisms of action in vivo. © 2005 American Society for Nutritional Sciences. Subject BiologyPhysiological SciencesFlavonoidsGlucuronidesPolyphenolsQuercetinTissue distributioncarbon 14flavonoidglucuronideisorhamnetinpolyphenol derivativequercetintamarixetinunclassified druganimal experimentanimal tissuearticlebioavailabilitybraincontrolled studyextractionfeedinghalf life timehearthigh performance liquid chromatographykidneylungmalemetabolitenonhumannutritionratspleenstatistical analysisswinetissue distributionwhite adipose tissueAnimalsBiological AvailabilityBody WeightChromatography, High Pressure LiquidMaleQuercetinRatsRats, Inbred F344SwineTissue DistributionSus scrofa To reference this document use: http://resolver.tudelft.nl/uuid:f2adeb90-8e70-4f2c-94a0-8f1b3ae82f23 TNO identifier 238597 ISSN 0022-3166 Source Journal of Nutrition, 135 (7), 1718-1725 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.