Title
Tissue distribution of quercetin in rats and pigs
Author
de Boer, V.C.J.
Dihal, A.A.
van der Woude, H.
Arts, I.C.W.
Wolffram, S.
Alink, G.M.
Rietjens, I.M.C.M.
Keijer, J.
Hollman, P.C.H.
TNO Kwaliteit van Leven
Publication year
2005
Abstract
Quercetin is a dietary polyphenolic compound with potentially beneficial effects on health. Claims that quercetin has biological effects are based mainly on in vitro studies with quercetin aglycone. However, quercetin is rapidly metabolized, and we have little knowledge of its availability to tissues. To assess the long-term tissue distribution of quercetin, 2 groups of rats were given a 0.1 or 1% quercetin diet [∼50 or 500 mg/kg body weight (wt)] for 11 wk. In addition, a 3-d study was done with pigs fed a diet containing 500 mg quercetin/kg body wt. Tissue concentrations of quercetin and quercetin metabolites were analyzed with an optimized extraction method. Quercetin and quercetin metabolites were widely distributed in rat tissues, with the highest concentrations in lungs (3.98 and 15.3 nmol/g tissue for the 0.1 and 1% quercetin diet, respectively) and the lowest in brain, white fat, and spleen. In the short-term pig study, liver (5.87 nmol/g tissue) and kidney (2.51 nmol/g tissue) contained high concentrations of quercetin and quercetin metabolites, whereas brain, heart, and spleen had low concentrations. These studies have for the first time identified target tissues of quercetin, which may help to understand its mechanisms of action in vivo. © 2005 American Society for Nutritional Sciences.
Subject
Biology
Physiological Sciences
Flavonoids
Glucuronides
Polyphenols
Quercetin
Tissue distribution
carbon 14
flavonoid
glucuronide
isorhamnetin
polyphenol derivative
quercetin
tamarixetin
unclassified drug
animal experiment
animal tissue
article
bioavailability
brain
controlled study
extraction
feeding
half life time
heart
high performance liquid chromatography
kidney
lung
male
metabolite
nonhuman
nutrition
rat
spleen
statistical analysis
swine
tissue distribution
white adipose tissue
Animals
Biological Availability
Body Weight
Chromatography, High Pressure Liquid
Male
Quercetin
Rats
Rats, Inbred F344
Swine
Tissue Distribution
Sus scrofa
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TNO identifier
238597
ISSN
0022-3166
Source
Journal of Nutrition, 135 (7), 1718-1725
Document type
article