Suitability of low-dose open food challenge data to supplement double-blind placebo-controlled data in generation of food allergen threshold dose distributions

Suitability of low-dose open food challenge data to supplement double-blind placebo-controlled data in generation of food allergen threshold dose distributions

Remington, B.C.
Westerhout, J.
Dubois, A.E.J.
Blom, W.M.
Kruizinga, A.G.
Taylor, S.L.
Houben, G.F.
Baumert, J.L.

2021

Food allergen threshold dose distributions are used in food allergen risk assessment to determine the level of risk within a food-allergic population to a defined exposure amount of allergenic food protein and to help inform allergen risk management decisions. There has been a long-standing interest in determining threshold dose distributions for different food allergens from a research and a risk management perspective.1-3 More recently, allergen risk management programmes utilizing population threshold dose distributions to inform the decision-making process have been endorsed by multiple international stakeholder groups and national agencies.4-7 The interest shown by all stakeholders regarding this area of research had placed an emphasis on gathering as many data points, from as many foods, as possible to better inform allergen risk assessments and risk management.

Food
Data
Allergen
Risk assessment

http://resolver.tudelft.nl/uuid:f194ec0d-df37-49f0-935f-495402d1db78

https://doi.org/10.1111/cea.13753

946584

0954-7894

Clinical and Experimental Allergy, 51 (51), 151-154

article