Title
Enhanced susceptibility of low-density lipoproteins to oxidation in coronary bypass patients with progression of atherosclerosis
Author
de Rijke, Y.B.
Verwey, H.F.
Vogelezang, C.J.M.
van der Velde, E.A.
Princen, H.M.G.
van der Laarse, A.
Bruschke, A.V.G.
van Berkel, T.J.C.
Gaubius Instituut TNO
Publication year
1995
Abstract
Oxidation of low-density lipoprotein (LDL) may play a causal role in atherosclerosis. In this study we analyzed whether the severity of progression of coronary atherosclerosis is related to the susceptibility of LDL to oxidative modification. On the basis of repeated coronary angiography, 28 coronary bypass patients were divided into two groups: group A, 12 patients with, and group B, 16 patients without progression of coronary atherosclerosis. The lag time, reflecting the resistance of LDL to oxidative modification, was significantly smaller in group A as compared with group B (81 ± 10 and 93 ± 15 min, respectively). Besides differences in cholesterol and apolipoprotein B concentrations, the difference in susceptibility of LDL to oxidation significantly contributes to the differences between the progression and the nonprogression group (P = 0.02). In the combined groups of patients, the lag phase of LDL for oxidation was positively correlated with LDL cholesterol ester to protein ratio (r = 0.53, P = 0.01). It is concluded that LDL samples obtained from coronary bypass patients differ with respect to their oxidizability depending on progression of atherosclerosis following coronary bypass surgery. Chemicals/CAS: Apolipoproteins; Ascorbic Acid, 50-81-7; Lipoproteins, LDL; Triglycerides; Vitamin E, 1406-18-4
Subject
Biology
apolipoprotein B
coronary artery bypass surgery
coronary atherosclerosis
lipid peroxidation
low-density lipoprotein
apolipoprotein a
apolipoprotein b
cholesterol
high density lipoprotein
low density lipoprotein
retinol
triacylglycerol
adult
aged
angiography
article
atherosclerosis
blood analysis
clinical article
controlled study
coronary artery bypass graft
human
human tissue
lipid analysis
lipid oxidation
male
priority journal
Apolipoproteins
Arteriosclerosis
Ascorbic Acid
Centrifugation, Density Gradient
Coronary Artery Bypass
Disease Progression
Follow-Up Studies
Humans
Lipoproteins, LDL
Male
Middle Aged
Oxidation-Reduction
Triglycerides
Vitamin E
To reference this document use:
http://resolver.tudelft.nl/uuid:ef0bd4e8-d68d-418c-b36a-4f60e714a81f
DOI
https://doi.org/10.1016/0009-8981(95)06163-0
TNO identifier
233105
ISSN
0009-8981
Source
Clinica Chimica Acta, 243 (2), 137-149
Document type
article