Print Email Facebook Twitter Walking or vitamin B for cognition in older adults with mild cognitive impairment? A randomised controlled trial Title Walking or vitamin B for cognition in older adults with mild cognitive impairment? A randomised controlled trial Author van Uffelen, J.G.Z. Chinapaw, M.J.M. van Mechelen, W. Hopman-Rock, M. TNO Kwaliteit van Leven Publication year 2008 Abstract Objective: To examine the effects of aerobic exercise or vitamin B supplementation on cognitive function in older adults with mild cognitive impairment (MCI). Design: Randomised placebo-controlled trial. Setting: General community. Participants: Community-dwelling adults aged 70-80 with MCI. Interventions : The 152 participants were randomly assigned to two interventions: (1) a twice-weekly, group-based, moderate-intensity walking programme (WP, n = 77) or a low-intensity placebo activity programme (n = 75) for one year; and (2) daily vitamin pill containing 5 mg folic acid, 0.4 mg vitamin B-12, 50 mg vitamin B-6 (FA/B12/B6, n = 78) or placebo pill (n = 74) for one year. Outcome measures: Cognitive function, measured with neuropsychological tests at baseline and after six and 12 months. Results: Median session attendance at the exercise programmes (25th-75th percentile) was 63% (2%-81%) and median compliance with taking pills (25th-75th percentile) was 100% (99%-100%). Gender was an effect modifier. Intention-to-treat analysis revealed no main intervention effect for either intervention. In women in the WP, attention (Stroop combination task) improved by 0.3 seconds (p = 0.04) and memory (auditory verbal learning test) by 0.04 words (p = 0.06) with each percentage increase in session attendance. In men attending at least 75% of the sessions, the WP improved memory (β 1.5 (95% CI: 0.1 to 3.0) words). Conclusion: The walking programme and/or FA/B12/B6 supplementation were not effective in improving cognition within one year. The walking programme, however, was efficacious in improving memory in men and memory and attention in women with better adherence. Trial registration: International Standard Randomised Controlled Trial Number Register, 19227688, http://www.controlled-trials.com/isrctn/. Chemicals / CAS: Folic Acid, 59-30-3; Vitamin B 12, 68-19-9; Vitamin B 6, 8059-24-3 Subject HealthLeefomgeving en gezondheidcyanocobalamin plus folic acid plus pyridoxineplacebovitamin B complexaerobic exerciseagedarticleattentionclinical trialcognitioncognitive defectcontrolled clinical trialcontrolled studydouble blind proceduredrug withdrawalelderly carefemalehealth programhumanmajor clinical studymalememorymemory disordermini mental state examinationpatient compliancepatient participationrandomized controlled trialsex differencesleep disordertreatment outcomevitamin supplementationwalkingAgedAged, 80 and overCognition DisordersDouble-Blind MethodExercise TherapyFemaleFolic AcidHumansMaleMemoryNetherlandsNeuropsychological TestsPatient ComplianceTreatment OutcomeVitamin B 12Vitamin B 6Walking To reference this document use: http://resolver.tudelft.nl/uuid:ee0bc785-f765-4111-a2c8-e3a0ee63b9fe DOI https://doi.org/10.1136/bjsm.2007.044735 TNO identifier 240781 ISSN 0306-3674 Source British Journal of Sports Medicine, 42 (5), 344-351 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.