Title
Mediterranean diet adherence and genetic background roles within a web-based nutritional intervention: The food4me study
Author
San-Cristobal, R.
Navas-Carretero, S.
Livingstone, K.M.
Celis-Morales, C.
Macready, A.L.
Fallaize, R.
O’Donovan, C.B.
Lambrinou, C.P.
Moschonis, G.
Marsaux, C.F.M.
Manios, Y.
Jarosz, M.
Daniel, H.
Gibney, E.R.
Brennan, L.
Drevon, C.A.
Gundersen, T.E.
Gibney, M.
Saris, W.H.M.
Lovegrove, J.A.
Grimaldi, K.
Parnell, L.D.
Bouwman, J.
Ommen, B.
Mathers, J.C.
Alfredo Martinez, J.
Publication year
2017
Abstract
Mediterranean Diet (MedDiet) adherence has been proven to produce numerous health benefits. In addition, nutrigenetic studies have explained some individual variations in the response to specific dietary patterns. The present research aimed to explore associations and potential interactions between MedDiet adherence and genetic background throughout the Food4Me web-based nutritional intervention. Dietary, anthropometrical and biochemical data from volunteers of the Food4Me study were collected at baseline and after 6 months. Several genetic variants related to metabolic risk features were also analysed. A Genetic Risk Score (GRS) was derived from risk alleles and a Mediterranean Diet Score (MDS), based on validated food intake data, was estimated. At baseline, there were no interactions between GRS and MDS categories for metabolic traits. Linear mixed model repeated measures analyses showed a significantly greater decrease in total cholesterol in participants with a low GRS after a 6-month period, compared to those with a high GRS. Meanwhile, a high baseline MDS was associated with greater decreases in Body Mass Index (BMI), waist circumference and glucose. There also was a significant interaction between GRS and the MedDiet after the follow-up period. Among subjects with a high GRS, those with a high MDS evidenced a highly significant reduction in total carotenoids, while among those with a low GRS, there was no difference associated with MDS levels. These results suggest that a higher MedDiet adherence induces beneficial effects on metabolic outcomes, which can be affected by the genetic background in some specific markers. © 2017 by the authors. Licensee MDPI, Basel, Switzerland. Chemicals/CAS: cholesterol, 57-88-5; glucose, 50-99-7, 84778-64-3
Subject
ELSS - Earth, Life and Social Sciences
Life
Healthy Living
Biomedical Innovation
Food4Me study
Genetic risk
Mediterranean diet
Obesity
Carotenoid
Cholesterol
Fatty acid
Glucose
Omega 3 fatty acid
Adult
Blood analysis
Body mass
Dietary compliance
DNA isolation
Female
Follow up
Food frequency questionnaire
Gene linkage disequilibrium
Genetic load
Genetic risk
Genotype
Human
Male
Phenotype
Quantitative trait locus
Randomized controlled trial (topic)
Single nucleotide polymorphism
Treatment outcome
Waist circumference
MSB - Microbiology and Systems Biology
To reference this document use:
http://resolver.tudelft.nl/uuid:eda6088c-5207-4459-9c71-1a2181203c4f
DOI
https://doi.org/10.3390/nu9101107
TNO identifier
781916
ISSN
2072-6643
Source
Nutrients, 9 (9)
Document type
article