Print Email Facebook Twitter Task-based dermal exposure models for regulatory risk assessment Title Task-based dermal exposure models for regulatory risk assessment Author Warren, N.D. Marquart, H. Christopher, Y. Laitinen, J. van Hemmen, J.J. TNO Kwaliteit van Leven Publication year 2006 Abstract The regulatory risk assessment of chemicals requires the estimation of occupational dermal exposure. Until recently, the models used were either based on limited data or were specific to a particular class of chemical or application. The EU project RISKOFDERM has gathered a considerable number of new measurements of dermal exposure together with detailed contextual information. This article describes the development of a set of generic task-based models capable of predicting potential dermal exposure to both solids and liquids in a wide range of situations. To facilitate modelling of the wide variety of dermal exposure situations six separate models were made for groupings of exposure scenarios called Dermal Exposure Operation units (DEO units). These task-based groupings cluster exposure scenarios with regard to the expected routes of dermal exposure and the expected influence of exposure determinants. Within these groupings linear mixed effect models were used to estimate the influence of various exposure determinants and to estimate components of variance. The models predict median potential dermal exposure rates for the hands and the rest of the body from the values of relevant exposure determinants. These rates are expressed as mg or μl product per minute. Using these median potential dermal exposure rates and an accompanying geometric standard deviation allows a range of exposure percentiles to be calculated. Crown Copyright 2006. Subject ChemistryFood and Chemical Risk AnalysisDermal exposureExposure modellingRisk assessmentIndustrial emissionsIndustrial hygieneOccupational risksRegulatory complianceVariational techniquesDermal Exposure Operation units (DEO units)Standard deviationIndustrial chemicalsChemical injuryExposureHandSkin injurySkin toxicityStatistical modelEnvironmental MonitoringHazardous SubstancesHumansModels, BiologicalOccupational ExposureSkin To reference this document use: http://resolver.tudelft.nl/uuid:ecff7108-4861-4f57-a070-0e6aa0bbad95 DOI https://doi.org/10.1093/annhyg/mel014 TNO identifier 239350 ISSN 0003-4878 Source Annals of Occupational Hygiene, 50 (5), 491-503 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.