Title
Motor function under lower and higher controlled processing demands in early and continuously treated phenylketonuria
Author
TNO Kwaliteit van Leven
Huijbregts, S.C.J.
van Spronsen, F.J.
Licht, R.
de Sonneville, L.M.J.
Berends, I.E.
Verkerk, P.H.
Sergeant, J.A.
Publication year
2003
Abstract
This study examined motor control in 61 early and continuously treated patients with phenylketonuria (PKU) and 69 control participants, aged 7 to 14 years. The pursuit task demanded concurrent planning and execution of unpredictable movements, whereas the tracking task required a highly automated circular movement that could be planned in advance. PKU patients showed significantly poorer motor control in both tasks compared with control participants. Deficits were particularly observed for younger patients (age < 11 years). Differences between control participants and PKU patients were significantly greater in the pursuit task compared with the tracking task, indicating more serious deficits when a higher level of controlled processing is required. Correlations with historical phenylalanine levels indicated a later maturation of the level of control required by the pursuit task compared with the tracking task. Chemicals/CAS: phenylalanine, 3617-44-5, 63-91-2; Phenylalanine, 63-91-2
Subject
amino acid blood level
brain maturation
central nervous system function
child
controlled study
eye tracking
human
information processing
major clinical study
motor control
motor dysfunction
motor performance
planning
prefrontal cortex
pursuit task
task performance
working memory
Adolescent
Age Factors
Case-Control Studies
Child
Female
Humans
Male
Motor Skills
Neuropsychological Tests
Phenylalanine
Phenylketonurias
Psychomotor Performance
Reaction Time
Task Performance and Analysis
2015 Life
CH - Child Health
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DOI
https://doi.org/10.1037/0894-4105.17.3.369
TNO identifier
237153
ISSN
0894-4105
Source
Neuropsychology, 17 (17), 369-379
Document type
article