Print Email Facebook Twitter Lactulose stimulates calcium absorption in postmenopausal women Title Lactulose stimulates calcium absorption in postmenopausal women Author van den Heuvel, E.G.H.M. Muijs, T. van Dokkum, W. Schaafsma, G. Centraal Instituut voor Voedingsonderzoek TNO Publication year 1999 Abstract Animal studies have indicated that calcium absorption is increased by lactulose, a synthetic disaccharide. Therefore, the influence of lactulose on calcium absorption was measured in postmenopausal women who may benefit from the possible enhancing effect of lactulose on calcium absorption. Twelve postmenopausal women drank 100 ml of water containing 5 or 10 g of lactulose or a reference substance at breakfast for 9 days. The three treatments were given according to a randomized, double-blind, cross-over design, separated by two 19-day wash-out periods. On the 8th day of each treatment period, 44Ca dissolved in orange juice was drunk immediately after the solution with the study substance and just before a standard breakfast with 162 mg of carrier calcium. Within half an hour, 48Ca was given intravenously. Based on isotope ratios measured in urine collected before and until 36 h after isotope administration, true fractional calcium absorption was calculated. Calcium absorption during the treatments with the reference substance, 5 g and 10 g of lactulose was (mean ± SD) 27.7 ± 7.7, 30.0 ± 7.6, and 32.2 ± 7.0, respectively. A significant difference in calcium absorption was found between the highest dose of lactulose and the reference treatment (p < 0.01). A significant linear trend was found between the dose of lactulose and its positive effect on calcium absorption. In conclusion, in postmenopausal women a 9-day consumption of lactulose increases calcium absorption in a dose- response way. More research is warranted to explore how lactulose stimulates calcium absorption and whether it is able to improve calcium balance and/or to attenuate the rate of aging bone loss. Subject NutritionLactuloseAdultAgingBone atrophyCalcium absorptionCalcium balanceCalcium metabolismClinical articleFemaleFermentationHumanIntestine absorptionPostmenopauseRisk benefit analysisSolubilityCalciumCalcium IsotopesCross-Over StudiesDose-Response Relationship, DrugDouble-Blind MethodFemaleHumansIntestinal AbsorptionLactuloseMiddle AgedPostmenopause To reference this document use: http://resolver.tudelft.nl/uuid:ec4a3422-ea8c-4058-b171-97cdab7987fb DOI https://doi.org/10.1359/jbmr.19188.8.131.521 TNO identifier 235092 ISSN 0884-0431 Source Journal of Bone and Mineral Research, 14 (7), 1211-1216 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.