Title
Nasal passages of Göttingen minipigs from the neonatal period to young adult
Author
Kuper, C.F.
Ernst, H.
van Oostrum, L.C.M.
Rittinghausen, S.
Penninks, A.H.
Ganderup, N.-C.
Wolterbeek, A.P.M.
Publication year
2012
Abstract
Histopathological examination of the nasal passages requires a standardized approach for recording lesion distribution patterns. Nasal diagrams provide guidance to map the lesions. Information on lesions exists for rodents, dogs, and monkeys, which all have been used in inhalation studies. Recently, minipigs have garnered interest as an inhalation model because minipigs resemble humans in many features of anatomy, physiology, and biochemistry and may be a good alternative to monkeys and dogs. The present work explored the microanatomy and histology of the nasal passages of Göttingen minipigs from postnatal day 1 until 6 months of age. Six nasal levels were selected, which allow examination of the squamous, transitional (nonciliated) and ciliated respiratory, and olfactory epithelia; the nasopharynx; and relevant structures such as the vomeronasal organ, olfactory bulb, and nasal/nasopharynx-associated lymphoid tissue. © 2012 by The Author(s).
Subject
Life Triskelion BV
QS - Quality & Safety TAP - Toxicology and Applied Pharmacology
EELS - Earth, Environmental and Life Sciences TNO Bedrijven
Healthy for Life
Healthy Living
inhalation
juvenile development
minipig
NALT
nasal levels
olfactory bulb
vomeronasal organ
To reference this document use:
http://resolver.tudelft.nl/uuid:ea92b356-cf17-4312-8b0d-8c8766664ebd
DOI
https://doi.org/10.1177/0192623311436175
TNO identifier
461070
ISSN
0192-6233
Source
Toxicologic Pathology, 40 (4), 656-666
Document type
article