Title
Lipid profiles reflecting high and low risk for coronary heart disease: Contribution of apolipoprotein E polymorphism and lifestyle
Author
Boer, J.M.A.
Feskens, E.J.M.
Schouten, E.G.
Havekes, L.M.
Seidell, J.C.
Kromhout, D.
Gaubius instituut TNO
Publication year
1998
Abstract
To elucidate the role of modifiable factors and the apolipoprotein E polymorphism in explaining lipid profiles reflecting low, average and high risk for coronary heart disease, we selected subjects from a large population-based study. Subjects with low total cholesterol (TC) (< 15th percentile) and high HDL-cholesterol levels (> 85th percentile) were randomly selected (n = 99) and represent subjects with a low risk lipid profile. Additionally, 95 subjects with total and HDL-cholesterol levels in the 15% around the population-median (median risk lipid profile) and 100 subjects with high TC (> 85th percentile) and low HDL-cholesterol levels (< 15th percentile) (high risk lipid profile) were selected. Compared with E3/3 subjects, the likelihood for a low risk lipid profile was considerably higher (odds ratio 14.3; 2.6-79) in female, but not in male E2-carriers (1.5; 0.3- 6.7). Smoking and alcohol consumption were independently associated with a low risk lipid profile in both genders, physical inactivity only in women. The odds ratio for a high risk lipid profile was elevated in male E4-carriers (4.9; 1.1-23) only. In addition to the E4 isoform, smoking and physical inactivity, overweight was the main determinant for a high risk lipid profile (odds ratio 16.8; 3.4-82). Male overweight E4-carriers had a 50 times higher likelihood of a high risk lipid profile than E3/3 men of normal weight. In women, only overweight was independently associated with a high risk lipid profile. Our results suggest that both modifiable factors and the apolipoprotein E polymorphism contribute to a lipid profile, reflecting low, average and high risk for coronary heart disease, but effects may be gender- specific.
Subject
Health
Apolipoprotein E polymorphism
HDL-cholesterol
Lipid profile
Modifiable risk factors
Total cholesterol
Adult
Alleles
Apolipoproteins E
Cholesterol
Cholesterol, HDL
Coronary Disease
Female
Humans
Life Style
Lipids
Male
Middle Aged
Odds Ratio
Phenotype
Polymorphism, Genetic
Risk Factors
To reference this document use:
http://resolver.tudelft.nl/uuid:e93d28eb-a41b-40d8-9149-f104eeee95da
DOI
https://doi.org/10.1016/s0021-9150(97)00231-1
TNO identifier
234359
ISSN
0021-9150
Source
Atherosclerosis, 136 (2), 395-402
Document type
article