Allergenicity assessment strategy for novel food proteins and protein sources

Allergenicity assessment strategy for novel food proteins and protein sources

Verhoeckx, K.
Broekman, H.
Knulst, A.
Houben, G.

2016

To solve the future food insecurity problem, alternative and sustainable protein sources (e.g. insects, rapeseed, fava bean and algae) are now being explored for the production of food and feed. To approve these novel protein sources for future food a comprehensive risk assessment is needed according to the European food legislation. Allergenicity risk assessment might pose some major difficulties, since detailed guidance on how to assess the allergenic potential of novel foods is not available. At present, the approach relies mostly on the guidance of allergenicity assessment for genetically modified (GM) plant foods. The most recent one was proposed by EFSA (2010 and 2011); “weight-of-evidence approach”. However this guidance is difficult to interpret, not completely applicable or validated for novel foods and therefore needs some adjustments. In this paper we propose a conceptual strategy which is based on the “weight-of-evidence approach” for food derived from GM plants and other strategies that were previously published in the literature. This strategy will give more guidance on how to assess the allergenicity of novel food proteins and protein sources. © 2016 Elsevier Inc. Chemicals / CAS immunoglobulin E, 37341-29-0; pepsin A, 9001-75-6; tropomyosin, 72067-79-9; Allergens; Vegetable Proteins

Allergenicity assessment
Cross-reactivity
De novo sensitisation
Novel food protein
allergen
immunoglobulin E
pepsin A
tropomyosin
allergen
plant protein
allergenicity
allergy test
cross reaction
food allergy
food processing
food safety
human
molecular phylogeny
nonhuman
Note
priority journal
protein analysis
protein expression
protein intake
protein stability
risk assessment
sequence homology
transgenic plant
adverse effects
animal
Food Hypersensitivity
food safety
genetically modified food
genetics
immunological procedures
immunology
practice guideline
product safety
standards
Allergens
Animals
Consumer Product Safety
Cross Reactions
Food Hypersensitivity
Food Safety
Food, Genetically Modified
Guidelines as Topic
Humans
Immunologic Tests
Plants, Genetically Modified
Risk Assessment
Vegetable Proteins

http://resolver.tudelft.nl/uuid:e874cc95-1890-4923-ba78-e783ab76bdd7

https://doi.org/10.1016/j.yrtph.2016.03.016

954794

0273-2300

article