Print Email Facebook Twitter Allergenicity assessment strategy for novel food proteins and protein sources Title Allergenicity assessment strategy for novel food proteins and protein sources Author Verhoeckx, K. Broekman, H. Knulst, A. Houben, G. Publication year 2016 Abstract To solve the future food insecurity problem, alternative and sustainable protein sources (e.g. insects, rapeseed, fava bean and algae) are now being explored for the production of food and feed. To approve these novel protein sources for future food a comprehensive risk assessment is needed according to the European food legislation. Allergenicity risk assessment might pose some major difficulties, since detailed guidance on how to assess the allergenic potential of novel foods is not available. At present, the approach relies mostly on the guidance of allergenicity assessment for genetically modified (GM) plant foods. The most recent one was proposed by EFSA (2010 and 2011); “weight-of-evidence approach”. However this guidance is difficult to interpret, not completely applicable or validated for novel foods and therefore needs some adjustments. In this paper we propose a conceptual strategy which is based on the “weight-of-evidence approach” for food derived from GM plants and other strategies that were previously published in the literature. This strategy will give more guidance on how to assess the allergenicity of novel food proteins and protein sources. © 2016 Elsevier Inc. Chemicals / CAS immunoglobulin E, 37341-29-0; pepsin A, 9001-75-6; tropomyosin, 72067-79-9; Allergens; Vegetable Proteins Subject Allergenicity assessmentCross-reactivityDe novo sensitisationNovel food proteinallergenimmunoglobulin Epepsin Atropomyosinallergenplant proteinallergenicityallergy testcross reactionfood allergyfood processingfood safetyhumanmolecular phylogenynonhumanNotepriority journalprotein analysisprotein expressionprotein intakeprotein stabilityrisk assessmentsequence homologytransgenic plantadverse effectsanimalFood Hypersensitivityfood safetygenetically modified foodgeneticsimmunological proceduresimmunologypractice guidelineproduct safetystandardsAllergensAnimalsConsumer Product SafetyCross ReactionsFood HypersensitivityFood SafetyFood, Genetically ModifiedGuidelines as TopicHumansImmunologic TestsPlants, Genetically ModifiedRisk AssessmentVegetable Proteins To reference this document use: http://resolver.tudelft.nl/uuid:e874cc95-1890-4923-ba78-e783ab76bdd7 DOI https://doi.org/10.1016/j.yrtph.2016.03.016 TNO identifier 954794 ISSN 0273-2300 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.