Title
Neurobehavioral effects of cyclohexane in rat and human
Author
Lammers, J.H.C.M.
Emmen, H.H.
Muijser, H.
Hoogendijk, E.M.G.
McKee, R.H.
Owen, D.E.
Kulig, B.M.
TNO Kwaliteit van Leven
Publication year
2009
Abstract
The neurobehavioral effects of inhaled cyclohexane in rats and humans are investigated to define relationships between internal doses and acute central nervous system effects. Rats are exposed for 3 consecutive days at target concentrations of 0, 1.4, 8, and 28 g/m3, 8 h/d. Measurements include standardized observational measures, spontaneous motor activity assessments, and learned visual discrimination performance. Cyclohexane concentrations in blood and brain are measured to assess internal exposure. Human volunteers are exposed for 4 hours to 86 or 860 mg/m3 in 2 test sessions. Neurobehavioral effects are measured using a computerized neurobehavioral test battery. In rats, there are slight reductions in psychomotor speed in the high-exposure group but minimal central nervous system effects. In humans, there are no significant treatment-related effects at the levels tested. © The Author(s) 2009.
Subject
Biology
Toxicology and Applied Pharmacology
Behavioral assessments
Central nervous system effects
Cyclohexane
Solvent neurotoxicity
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http://resolver.tudelft.nl/uuid:e50e83c5-e40f-4b9e-a7d7-ededd054fd06
DOI
https://doi.org/10.1177/1091581809345534
TNO identifier
275976
ISSN
1091-5818
Source
International Journal of Toxicology, 28 (6), 488-497
Document type
article