Title
Dietary protein, blood pressure and renal function in renal transplant recipients
Author
van den Berg, E.
Engberink, M.F.
Brink, E.J.
van Baak, M.A.
Gans, R.O.B.
Navis, G.
Bakker, S.J.L.
Publication year
2013
Abstract
Hypertension is highly prevalent among renal transplant recipients (RTR) and a risk factor for graft failure and cardiovascular events. Protein intake has been claimed to affect blood pressure (BP) in the general population and may affect renal function. We examined the association of dietary protein with BP and renal function in RTR. We included 625 RTR (age 53 (sd 13) years; 57 % male). Protein intake was assessed with a FFQ, differentiating between animal and plant protein. BP was measured according to a strict protocol. Creatinine clearance and albuminuria were measured as renal parameters. Protein intake was 83 (sd 12) g/d, of which 63 % derived from animal sources. BP was 136 (sd 17) mmHg systolic (SBP) and 83 (sd 11) mmHg diastolic (DBP). Creatinine clearance was 66 (sd 26) ml/min; albuminuria 41 (10-178) mg/24 h. An inverse, though statistically insignificant, association was found between the total protein intake and both SBP (β =-2·22 mmHg per sd, P= 0·07) and DBP (β =-0·48 mmHg per sd, P= 0·5). Protein intake was not associated with creatinine clearance. Although albuminuria was slightly higher in the highest tertile of animal protein intake compared with the lowest tertile (66 v. 33 mg/d, respectively, P= 0·03), linear regression analyses did not reveal significant associations between dietary protein and albuminuria. Protein intake exceeded the current recommendations. Nevertheless, within the range of protein intake in our RTR population, we found no evidence for an association of dietary protein with BP and renal function. Intervention studies focusing on different protein types are warranted to clarify their effect on BP and renal function in RTR. © 2012 The Authors.
Subject
Blood pressure
Protein intake
Renal transplantation
Biomedical Innovation
Healthy Living
Life
PHS - Pharmacokinetics & Human Studies
EELS - Earth, Environmental and Life Sciences
To reference this document use:
http://resolver.tudelft.nl/uuid:e4756093-6aba-4ea9-b226-14ba99875aeb
DOI
https://doi.org/10.1017/s0007114512003455
TNO identifier
472020
ISSN
0007-1145
Source
British Journal of Nutrition, 109 (109), 1463-1470
Document type
article