Title
β-Lactam and glycopeptide antibiotics: First and last line of defense?
Author
Jovetic, S.
Zhu, Y.
Marcone, G.L.
Marinelli, F.
Tramper, J.
TNO Kwaliteit van Leven
Publication year
2010
Abstract
Most infections are caused by bacteria, many of which are ever-evolving and resistant to nearly all available antibiotics. β-Lactams and glycopeptides are used to combat these infections by inhibiting bacterial cell-wall synthesis. This mechanism remains an interesting target in the search for new antibiotics in light of failed genomic approaches and the limited input of major pharmaceutical companies. Several strategies have enriched the pipeline of bacterial cell-wall inhibitors; examples include combining screening strategies with lesser-explored microbial diversity, or reinventing known scaffolds based on structure-function relationships. Drugs developed using novel strategies will contribute to the arsenal in fight against the continued emergence of bacterial resistance. © 2010 Elsevier Ltd.
Subject
Biology
Biomedical Research
To reference this document use:
http://resolver.tudelft.nl/uuid:e3018e43-a7e8-4f6a-869f-9c2ac7307442
TNO identifier
425111
ISSN
0167-7799
Source
Trends in Biotechnology, 28 (12), 596-604
Document type
article