Title
Phenotypic flexibility in nutrition research to quantify human variability: building the bridge to personalized nutrition
Author
Wopereis, S.
Publication year
2022
Abstract
Phenotypic flexibility is a methodology that accurately assesses health in terms of mechanistic understanding of the interrelationship of multiple metabolic and physiological processes. This starts from the perspective that a healthy person is better able to cope with changes in environmental stressors that affect homeostasis compared to people with a compromised health state. The term "phenotypic flexibility" expresses the cumulative ability of overarching physiological processes to return to homeostatic levels after short term perturbations. The concept of phenotypic flexibility to define biomarkers for nutrition related health was introduced in 2009 in the area of health optimization and prevention and delay of non-communicable disease. The core approach consists of the combination of imposing a challenge test to the body followed by time-resolved analysis of multiple biomarkers. This new approach may better facilitate nutritional health research in intervention studies since it may show effects on early derailed physiological markers and the biomarker response can be extended by perturbing the system, thereby making them more sensitive in detecting health effects from food and nutrition. At the same time, interindividual variation can also be extended and compressed by challenge tests, facilitating the bridge to personalized nutrition. This review will overview where the science is in this research arena and what the phenotypic flexibility potential is for the nutrition field. (C) 2022 Cambridge University Press. All rights reserved.
Subject
Health quantification
Nutritional challenge test
Phenotyping
Prevention of non-communicable diseases
Tolerance test
To reference this document use:
http://resolver.tudelft.nl/uuid:e2941fe2-5d5d-4b3b-b415-f7438971f24c
DOI
https://doi.org/10.1017/s0029665122002853
TNO identifier
980912
Publisher
Cambridge University Press
ISSN
0029-6651
Source
Proceedings of the Nutrition Society, 1-3
Bibliographical note
Meeting: The Nutrition Society Summer Conference 2022 was hosted collaboratively by Sheffield Hallam University, the University of Sheffield and Sheffield City Council on 12–15 July 2022. Conference on Food and nutrition: Pathways to a sustainable future Symposia/Award: Understanding mechanisms for health.
Document type
conference paper