Print Email Facebook Twitter Cytogenetic findings in mouse multiple myeloma and Waldenström's macroglobulinemia Title Cytogenetic findings in mouse multiple myeloma and Waldenström's macroglobulinemia Author van den Akker, Th.W. Radl, J. Franken-Postma, E. Hagemeijer, A. Gaubius Instituut TNO Publication year 1996 Abstract Multiple myeloma (MM) and Waldenström's macroglobulinemia-like lymphoma (MW) appear spontaneously in C57BL/KaLwRij mice at a frequency of 0.5% and 0.2%, respectively. They can readily be propagated by intravenous transfer of mainly bone marrow or spleen cells into syngeneic recipients. Previous studies demonstrated that these mouse malignant monoclonal gammopathies (MMG) show clinical and biologic features that closely resemble those of the corresponding human diseases and thus could be used as experimental models. We report on cytogenetic analysis of two mouse MW and five MM in vivo cell lines of the 5TMM series propagated in syngeneic mice. These studies demonstrated clonal abnormalities in all cell lines, hyperdiploid karyotype in both MW and one MM lines, and hypotriploidy, hypertriploidy, or hypotetraploidy in the other lines. Structural abnormalities of chromosome 15 were observed in all MM lines. In the five MM lines, frequent rearrangements were also found for chromosome numbers 1, 2, 5, and 12. A single chromosomal abnormality, as found in induced mouse plasmacytomas and resembling Burkitt lymphoma, was not found in mouse MM and MW. It was concluded that spontaneously originating C57BL MM of the 5T series is a better model for human MM than pristane-induced BALB/c or NZB plasmacytoma. Subject Biologyanimal cellanimal experimentanimal modelanimal tissuearticlebone marrow cellburkitt lymphomacell transferchromosome aberrationchromosome analysiscontrolled studygammopathygene rearrangementmousemultiple myelomanonhumanplasmacytomapriority journaltriploidywaldenstroem macroglobulinemiaAnimalsChromosome AberrationsFemaleGenes, ImmunoglobulinHumansKaryotypingMaleMiceMice, Inbred C57BLMultiple MyelomaNeoplasm TransplantationTumor Cells, CulturedWaldenstrom Macroglobulinemia To reference this document use: http://resolver.tudelft.nl/uuid:e06281b6-a3b0-4667-9b10-c2374c5eda2a DOI https://doi.org/10.1016/0165-4608(95)00169-7 TNO identifier 233203 ISSN 0165-4608 Source Cancer Genetics and Cytogenetics, 86 (2), 156-161 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.