Title
Ring-extended derivatives of gramicidin S with furanoid sugar amino acids in the turn region have enhanced antimicrobial activity
Author
Knijnenburg, A.D.
Spalburg, E.
de Neeling, A.J.
Mars-Groenendijk, R.H.
Noort, D.
Grotenbreg, G.M.
van der Marel, G.A.
Overkleeft, H.S.
Overhand, M.
TNO Defensie en Veiligheid
Publication year
2009
Abstract
(Chemical Equation Presented) A series of ring-extended gramicidin S (GS) derivatives containing furanoid sugar amino acids were evaluated. Although the extended GS derivatives have a less well-defined secondary structure as determined by NMR and CD, some derivatives show an improved biological profile, namely, an increased antibacterial activity and decreased hemolytic activity. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
Subject
Defence
β turns
Antibiotics
Cyclic peptides
Gramicidin S
Sugar amino acids
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http://resolver.tudelft.nl/uuid:e05a6988-d71a-4cc4-aa10-fa40dbb0020e
DOI
https://doi.org/10.1002/cmdc.200900379
TNO identifier
275971
ISSN
1860-7179
Source
ChemMedChem, 4 (12), 1976-1979
Document type
article