Title
Grafting of venous leg ulcers. An intraindividual comparison between cultured skin equivalents and full-thickness skin punch grafts
Author
Medisch Biologisch Laboratorium TNO
Mol, M.A.E.
Nanninga, P.B.
van Eendenburg, J.P.
Westerhof, W.
Mekkes, J.R.
van Ginkel, C.J.W.
Publication year
1991
Abstract
Skin equivalents that consisted of a noncontracted collagen gel populated with allogeneic fibroblasts and covered with autologous cultured keratinocytes were used for grafting venous leg ulcers. The results were compared in the same patient with those obtained with a routinely used standard method of grafting with autologous full-thickness punch grafts. The skin equivalents and the punch grafts were grafted successfully in four of five patients. The median healing time of ulcers grafted with skin equivalents was 18 days whereas that of ulcers covered with punch grafts was 15 days. The cosmetic appearance of the skin equivalent-grafted ulcers was better than that of the punch-grafted ulcers. Chemicals/CAS: collagen, 9007-34-5; Collagen, 9007-34-5.
Subject
Collagen
Aged
Cell culture
Clinical article
Female
Fibroblast
Human
Human tissue
Keratinocyte
Leg ulcer
Male
Priority journal
Skin graft
Aged
Aged, 80 and over
Cells, Cultured
Chronic Disease
Collagen
Comparative Study
Female
Follow-Up Studies
Human
Leg Ulcer
Male
Skin
Skin Transplantation
Transplantation, Homologous
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TNO identifier
231470
ISSN
0190-9622
Source
Journal of the American Academy of Dermatology, 24 (24), 77-82
Document type
article