Title
Exposure to combinations of substances: A system for assessing health risks
Author
Feron, V.J.
van Vliet, P.W.
Notten, W.R.F.
TNO Voeding
Publication year
2004
Abstract
Combined exposures may be categorised as specified combinations or mixtures of substances, depending on composition and exposure scenario. The major characteristic of a specified combination is known composition and that of a mixture simultaneous exposure. A framework was developed as a guide for safety evaluation of combined exposures. This framework offers the possibility to evaluate mixtures as a single entity, or as a number of fractions or individual constituents. The evaluation of specified combinations will often focus on the individual components. To reduce the safety evaluation of complex exposures to manageable proportions, the "top n" and "pseudo top n" approaches were introduced, n representing the n most "risky" chemicals or groups of chemicals, respectively. To select the best method, the framework should always be walked through in its entirety, considering all options. The Mumtaz-Durkin weight-of-evidence approach is included as a prioritization instrument for combined exposures. It is based on hazard indices supplemented with qualitative and quantitative weighting and interaction factors. © 2004 Elsevier B.V. All rights reserved.
Subject
Chemistry Safety Health
Food and Chemical Risk Analysis
"Pseudo top n" approach
Combined exposures
Mixtures
Prioritization
Specified combinations
System for risk assessment
Top n approach
aspartame
benzene
butylated hydroxyanisole
food additive
sodium metabisulfite
sulfur dioxide
tobacco smoke
toxic substance
analytic method
biosafety
chemical composition
environmental exposure
exhaust gas
health hazard
priority journal
qualitative analysis
quantitative analysis
review
risk assessment
welding fume
To reference this document use:
http://resolver.tudelft.nl/uuid:dd647276-ffae-4ec6-b19c-4c3675fd2bad
DOI
https://doi.org/10.1016/j.etap.2003.11.009
TNO identifier
238182
ISSN
1382-6689
Source
Environmental Toxicology and Pharmacology, 18 (3 SPEC.ISS.), 215-222
Document type
article