Title
The SCID-hu mouse as a tool in immunotoxicological risk assessment: Effects of 2-acetyl-4(5)-tetrahydroxybutyl-imidazole (THI) and di-n-butyltin dichloride (DBTC) on the human thymus in SCID-hu mice
Author
de Heer, C.
Schuurman, H.J.
Houben, G.F.
Pieters, R.H.H.
Penninks, A.H.
van Loveren, H.
Centraal Instituut voor Voedingsonderzoek TNO
Publication year
1995
Abstract
SCID mice engrafted with human fetal thymus and liver tissue fragments (SCID-hu mice) are currently considered as a new tool in human immunotoxicological risk assessment. Testing of various immunotoxicants exerting thymotoxicity via different intrathymic target cell types is necessary for validation of this model. Therefore, SCID-hu mice were exposed to 2-acetyl-4(5)-(1,2,3,4-tetrahydroxybutyl)-imidazole (THI), the immunotoxic component in the food additive, Caramel Colour III, or the organotin compound, di-n-butyltin dichloride (DBTC). Histopathological examination of the human thymus grafts of SCID-hu mice either exposed to THI or to DBTC showed a reduction in the relative size of the thymus cortex, an effect also described in rodents, These results indicate that the human thymus is a target for the immunotoxic action of both THI and DBTC. In addition, they indicate the promising potential of the SCID-hu mouse model as a tool for human immunotoxicological risk assessment.
Subject
Nutrition
Caramel colour III
Immunotoxicology
Organotins
Risk assessment
SCID-hu
Thymus
2 acetyl 4 (1,2,3,4 tetrahydroxybutyl)imidazole
Dibutyltin dichloride
Food additive
Imidazole derivative
Animal experiment
Animal model
Animal tissue
Controlled study
Female
Histopathology
Immunotoxicity
Mouse
Nonhuman
Priority journal
Risk assessment
Thymus
Ammonia
Animal
Female
Food Coloring Agents
Human
Imidazoles
Immunosuppressive Agents
Mice
Mice, SCID
Organotin Compounds
Risk Assessment
Specific Pathogen-Free Organisms
Support, Non-U.S. Gov't
Teratogens
Thymus Gland
Animalia
Rodentia
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http://resolver.tudelft.nl/uuid:dd5280ed-edc9-458d-a1ae-02596f9f5bf2
DOI
https://doi.org/10.1016/0300-483x(95)03093-u
TNO identifier
233014
ISSN
0300-483X
Source
Toxicology, 100 (1-3), 203-211
Document type
article