Title
Myricetin stimulates the absorption of the pro-carcinogen PhIP
Author
Schutte, M.E.
van de Sandt, J.J.M.
Alink, G.M.
Groten, J.P.
Rietjens, I.M.C.M.
TNO Kwaliteit van Leven
Publication year
2006
Abstract
The effect of the flavonoid myricetin on the transport of the pro-carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) through differentiated Caco-2 monolayers, a model for the intestinal epithelium, is described. Myricetin causes an increase of the transport of PhIP from the apical to the basolateral compartment. This effect was observed at physiologically relevant concentrations of PhIP and myricetin. Cyclosporin A (MRP2 inhibitor) but not PSC833 (P-gp inhibitor) showed a similar effect on PhIP transport. The results indicate that myricetin induces an increased basolateral uptake of the pro-carcinogen PhIP, in part through inhibition of the MRP2 mediated excretion of PhIP from the intestinal cells back to the lumen. © 2005 Elsevier Ireland Ltd. All rights reserved.
Subject
Biology
Biomedical Research
ABC transporter
Apparent permeability
Caco-2
Myricetin
PhIP
2 amino 1 methyl 6 phenylimidazo[4,5 b]pyridine
carcinogen
cyclosporin A
glycoprotein P inhibitor
multidrug resistance protein 2
myricetin
valspodar
absorption
article
cell differentiation
cell strain CACO 2
cell transport
concentration (parameters)
excretion
human
human cell
intestine epithelium cell
priority journal
stimulation
Absorption
ATP-Binding Cassette Transporters
Caco-2 Cells
Carcinogens
Flavonoids
Humans
Imidazoles
Membrane Transport Proteins
Multidrug Resistance-Associated Proteins
Permeability
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http://resolver.tudelft.nl/uuid:dd4f7947-242e-4b80-b2e8-db7d3472ab79
DOI
https://doi.org/10.1016/j.canlet.2005.01.020
TNO identifier
239087
ISSN
0304-3835
Source
Cancer Letters, 231 (1), 36-42
Document type
article