Myricetin stimulates the absorption of the pro-carcinogen PhIP
van de Sandt, J.J.M.
TNO Kwaliteit van Leven
The effect of the flavonoid myricetin on the transport of the pro-carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) through differentiated Caco-2 monolayers, a model for the intestinal epithelium, is described. Myricetin causes an increase of the transport of PhIP from the apical to the basolateral compartment. This effect was observed at physiologically relevant concentrations of PhIP and myricetin. Cyclosporin A (MRP2 inhibitor) but not PSC833 (P-gp inhibitor) showed a similar effect on PhIP transport. The results indicate that myricetin induces an increased basolateral uptake of the pro-carcinogen PhIP, in part through inhibition of the MRP2 mediated excretion of PhIP from the intestinal cells back to the lumen. © 2005 Elsevier Ireland Ltd. All rights reserved.
To reference this document use:
2 amino 1 methyl 6 phenylimidazo[4,5 b]pyridine
glycoprotein P inhibitor
multidrug resistance protein 2
cell strain CACO 2
intestine epithelium cell
ATP-Binding Cassette Transporters
Membrane Transport Proteins
Multidrug Resistance-Associated Proteins
Cancer Letters, 231 (1), 36-42