Title
Review of RBE values of 15 MeV neutrons for effects on normal tissues
Author
Broerse, J.J.
Radiobiologisch Instituut TNO
Publication year
1974
Abstract
Values of the relative biological effectiveness (RBE) of fast neutrons for effect on normal tissue depend not only on the neutron energy and the dose, but also on the type of tissue irradiated. Values of the RBE of 15 MeV neutrons are reviewed for rapidly proliferating rodent tissue, such as mouse bone marrow, mouse intestine and rat skin treated with single and fractionated irradiations. In addition, RBE values were obtained for rodent tissue with relatively long cell life times, such as the vascular endothelium, the spinal cord and the lung. In general, the normal tissue data indicate that for doses between 50 and 250 rad the RBE values range up to values of about 2, but depend on the fractionation regimen.
Subject
bone marrow
fast neutron radiation
injury
intestine
lung
methodology
mouse
neutron radiation
rat
relative biologic effectiveness
spinal cord
theoretical study
therapy
Animal
Blood Vessels
Bone Marrow
Cells, Cultured
Comparative Study
Dose-Response Relationship, Radiation
Fast Neutrons
Hematopoietic Stem Cells
Intestines
Lung
Mice
Neoplasms
Neutrons
Radiation Injuries, Experimental
Radiotherapy, High-Energy
Rats
Skin
Spinal Cord
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TNO identifier
227778
ISSN
0277-5379
Source
European Journal of Cancer and Clinical Oncology, 10 (4), 225-230
Document type
article