Print Email Facebook Twitter Association between trans fatty acid intake and cardiovascular risk factors in Europe: The TRANSFAIR study Title Association between trans fatty acid intake and cardiovascular risk factors in Europe: The TRANSFAIR study Author van de Vijver, L.P.L. Kardinaal, A.F.M. Couet, C. Aro, A. Kafatos, A. Steingrimsdottir, L. Amorim Cruz, J.A. Moreiras, O. Becker, W. van Amelsvoort, J.M.M. Vidal-Jessel, S. Salminen, I. Moschandreas, J. Sigfússon, N. Martins, I. Carbajal, A. Ytterfors, A. van Poppel, G. Publication year 2000 Abstract Background: High intakes of trans fatty acids (TFA) have been found to exert an undersirable effect on serum lipid profiles, and thus may increase the risk for cardiovascular disease. Objective: Investigation of the association between TFA intake and serum lipids. Design: Cross-sectional study in eight European countries (Finland, France, Greece, Iceland, The Netherlands, Portugal, Spain, Sweden) among 327 men and 299 women (50-65 y). Using a dietary history method, food consumption was assessed and TFA intake was calculated with recent figures on TFA levels of foods, collected in the TRANSFAIR study. Results: Mean (±s.d.) TFA intake was 2.40 ± 1.53 g/day for men and 1.98±1.49 g/day for women (0.87±0.48% and 0.95±0.55% of energy, respectively), with the highest consumption in Iceland and the lowest in the Mediterranean countries. No associations were found between total TFA intake and LDL, HDL or LDL/HDL ratio after adjustment for cardiovascular risk factors. Additional adjustment for other fatty acid clusters resulted in a significant inverse trend between total TFA intake and total cholesterol (P(trend)<0.03). The most abundantly occuring TFA isomer, C18:1 t, contributed substantially to this inverse association. The TFA isomers C14:1 t9, C16:1 t9 and C22:1 t were not associated or were positively associated with LDL or total cholesterol. Conclusions: From this study we conclude that at the current European intake levels of trans fatty acids they are not associated with an unfavourable serum lipid profile. Subject fatty acidhigh density lipoproteinlow density lipoproteinadultagedarticlecardiovascular diseasecholesterol blood levelcontrolled studydisease associationEuropefat intakefemalefood intakehumanlipid blood levellipid compositionmajor clinical studymalerisk factortrans isomerAdipose TissueAgedCardiovascular DiseasesCholesterolCross-Sectional StudiesDiet RecordsDietary FatsEnergy IntakeEuropeFatty AcidsFemaleHumansIsomerismLinear ModelsLipidsLipoproteins, HDLLipoproteins, LDLMaleMiddle AgedRisk Factors To reference this document use: http://resolver.tudelft.nl/uuid:dbc641dc-e990-4d95-9092-a2d6ce3b3dc3 DOI https://doi.org/10.1038/sj.ejcn.1600906 TNO identifier 235517 ISSN 0954-3007 Source European Journal of Clinical Nutrition, 54 (2), 126-135 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.