Title
Association between trans fatty acid intake and cardiovascular risk factors in Europe: The TRANSFAIR study
Author
van de Vijver, L.P.L.
Kardinaal, A.F.M.
Couet, C.
Aro, A.
Kafatos, A.
Steingrimsdottir, L.
Amorim Cruz, J.A.
Moreiras, O.
Becker, W.
van Amelsvoort, J.M.M.
Vidal-Jessel, S.
Salminen, I.
Moschandreas, J.
Sigfússon, N.
Martins, I.
Carbajal, A.
Ytterfors, A.
van Poppel, G.
Publication year
2000
Abstract
Background: High intakes of trans fatty acids (TFA) have been found to exert an undersirable effect on serum lipid profiles, and thus may increase the risk for cardiovascular disease. Objective: Investigation of the association between TFA intake and serum lipids. Design: Cross-sectional study in eight European countries (Finland, France, Greece, Iceland, The Netherlands, Portugal, Spain, Sweden) among 327 men and 299 women (50-65 y). Using a dietary history method, food consumption was assessed and TFA intake was calculated with recent figures on TFA levels of foods, collected in the TRANSFAIR study. Results: Mean (±s.d.) TFA intake was 2.40 ± 1.53 g/day for men and 1.98±1.49 g/day for women (0.87±0.48% and 0.95±0.55% of energy, respectively), with the highest consumption in Iceland and the lowest in the Mediterranean countries. No associations were found between total TFA intake and LDL, HDL or LDL/HDL ratio after adjustment for cardiovascular risk factors. Additional adjustment for other fatty acid clusters resulted in a significant inverse trend between total TFA intake and total cholesterol (P(trend)<0.03). The most abundantly occuring TFA isomer, C18:1 t, contributed substantially to this inverse association. The TFA isomers C14:1 t9, C16:1 t9 and C22:1 t were not associated or were positively associated with LDL or total cholesterol. Conclusions: From this study we conclude that at the current European intake levels of trans fatty acids they are not associated with an unfavourable serum lipid profile.
Subject
fatty acid
high density lipoprotein
low density lipoprotein
adult
aged
article
cardiovascular disease
cholesterol blood level
controlled study
disease association
Europe
fat intake
female
food intake
human
lipid blood level
lipid composition
major clinical study
male
risk factor
trans isomer
Adipose Tissue
Aged
Cardiovascular Diseases
Cholesterol
Cross-Sectional Studies
Diet Records
Dietary Fats
Energy Intake
Europe
Fatty Acids
Female
Humans
Isomerism
Linear Models
Lipids
Lipoproteins, HDL
Lipoproteins, LDL
Male
Middle Aged
Risk Factors
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http://resolver.tudelft.nl/uuid:dbc641dc-e990-4d95-9092-a2d6ce3b3dc3
DOI
https://doi.org/10.1038/sj.ejcn.1600906
TNO identifier
235517
ISSN
0954-3007
Source
European Journal of Clinical Nutrition, 54 (2), 126-135
Document type
article