Title
Effect of satiety on brain activation during chocolate tasting in men and women
Author
Smeets, P.A.M.
de Graaf, C.
Stafleu, A.
van Osch, M.J.P.
Nievelstein, R.A.J.
van der Grond, J.
TNO Kwaliteit van Leven
Publication year
2006
Abstract
Background: The brain plays a crucial role in the decision to eat, integrating multiple hormonal and neural signals. A key factor controlling food intake is selective satiety, ie, the phenomenon that the motivation to eat more of a food decreases more than does the motivation to eat foods not eaten. Objective: We investigated the effect of satiation with chocolate on the brain activation associated with chocolate taste in men and women. Design: Twelve men and 12 women participated. Subjects fasted overnight and were scanned by use of functional magnetic resonance imaging while tasting chocolate milk, before and after eating chocolate until they were satiated. Results: In men, chocolate satiation was associated with increased taste activation in the ventral striatum, insula, and orbitofrontal and medial orbitofrontal cortex and with decreased taste activation in somatosensory areas. Women showed increased taste activation in the precentral gyrus, superior temporal gyrus, and putamen and decreased taste activation in the hypothalamus and amygdala. Sex differences in the effect of chocolate satiation were found in the hypothalamus, ventral striatum, and medial prefrontal cortex (all P < 0.005). Conclusions: Our results indicate that men and women differ in their response to satiation and suggest that the regulation of food intake by the brain may vary between the sexes. Therefore, sex differences are a covariate of interest in studies of the brain's responses to food. © 2006 American Society for Nutrition.
Subject
Nutrition
Food and Chemical Risk Analysis
Brain
Functional magnetic resonance imaging
Functional MRI
Satiation
Satiety
Satiety response
Sex differences
adult
amygdaloid nucleus
article
brain function
brain region
cacao
controlled study
corpus striatum
diet restriction
female
human
hypothalamus
insula
male
normal human
nuclear magnetic resonance imaging
orbital cortex
psychophysiology
putamen
somatosensory cortex
taste acuity
temporal lobe
appetite
beverage
brain
clinical trial
drug effect
metabolism
satiety
sexual development
taste
plant extract
sugar
Adult
Appetite
Beverages
Brain
Cacao
Candy
Female
Humans
Magnetic Resonance Imaging
Male
Plant Extracts
Satiation
Sex Characteristics
Taste
To reference this document use:
http://resolver.tudelft.nl/uuid:db9e3e3f-d292-42fe-97ef-70e5b0201b65
TNO identifier
239294
ISSN
0002-9165
Source
American Journal of Clinical Nutrition, 83 (6), 1297-1305
Document type
article