Print Email Facebook Twitter Role of vitamin A in liver fibrosis Title Role of vitamin A in liver fibrosis Author Knook, D.L. Bosma, A. Seifert, W.F. Instituut voor Verouderings- en Vaatziekten Onderzoek TNO Publication year 1995 Abstract The relationship between vitamin A and liver fibrosis was studied with a CCl4-induced fibrosis model in rats. Depending on the time of administration, vitamin A can potentiate or reduce fibrosis: when present during CCl4-treatment parenchymal cell damage and fibrosis were enhanced, whereas vitamin A post-treatment strongly reduced fibrosis. Enhanced fibrosis was also found in rats with low hepatic retinoid levels. Administration of β-carotene during CCl4-treatment reduced several signs of fibrosis. The notion that liver retinoids play an important role in hepatic fibrogenesis is discussed. Subject Biologyβ-CaroteneCCl4CirrhosisCollagen metabolismFat-storing cellsFibrogenesisFibrosisbeta carotenecarbon tetrachlorideretinolanimal modelconference papercontrolled studynonhumanretinol deficiencyretinol intoxicationAnimalAntioxidantsbeta CaroteneCarbon TetrachlorideCarotenoidsFemaleLiver Cirrhosis, ExperimentalRatsVitamin A To reference this document use: http://resolver.tudelft.nl/uuid:daf9a373-68f4-4ca4-83e9-e208ff5602de TNO identifier 232840 ISSN 0815-9319 Source Journal of Gastroenterology and Hepatology, 10 (SUPPL. 1), S47-S49 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.