Role of vitamin A in liver fibrosis

Title

Role of vitamin A in liver fibrosis

 Author

Knook, D.L.
Bosma, A.
Seifert, W.F.
Instituut voor Verouderings- en Vaatziekten Onderzoek TNO

Publication year

1995

 Abstract

The relationship between vitamin A and liver fibrosis was studied with a CCl4-induced fibrosis model in rats. Depending on the time of administration, vitamin A can potentiate or reduce fibrosis: when present during CCl4-treatment parenchymal cell damage and fibrosis were enhanced, whereas vitamin A post-treatment strongly reduced fibrosis. Enhanced fibrosis was also found in rats with low hepatic retinoid levels. Administration of β-carotene during CCl4-treatment reduced several signs of fibrosis. The notion that liver retinoids play an important role in hepatic fibrogenesis is discussed.

 Subject

Biology
β-Carotene
CCl4
Cirrhosis
Collagen metabolism
Fat-storing cells
Fibrogenesis
Fibrosis
beta carotene
carbon tetrachloride
retinol
animal model
conference paper
controlled study
nonhuman
retinol deficiency
retinol intoxication
Animal
Antioxidants
beta Carotene
Carbon Tetrachloride
Carotenoids
Female
Liver Cirrhosis, Experimental
Rats
Vitamin A

 To reference this document use:

http://resolver.tudelft.nl/uuid:daf9a373-68f4-4ca4-83e9-e208ff5602de

 TNO identifier

232840

 ISSN

0815-9319

 Source

Journal of Gastroenterology and Hepatology, 10 (SUPPL. 1), S47-S49

 Document type

article
Files
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