Print Email Facebook Twitter A decade of microfluidic analysis coupled with electrospray mass spectrometry: An overview Title A decade of microfluidic analysis coupled with electrospray mass spectrometry: An overview Author Koster, S. Verpoorte, E. TNO Kwaliteit van Leven Publication year 2007 Abstract This review presents a thorough overview covering the period 1997-2006 of microfluidic chips coupled to mass spectrometry through an electrospray interface. The different types of fabrication processes and materials used to fabricate these chips throughout this period are discussed. Three 'eras' of interfaces are clearly distinguished. The earliest approach involves spraying from the edge of a chip, while later devices either incorporate a standard fused-silica emitter inserted into the device or fully integrated emitters formed during chip fabrication. A summary of microfluidic-electrospray devices for performing separations and sample pretreatment steps before sample introduction into the mass spectrometer is also presented. © The Royal Society of Chemistry. Chemicals / CAS: silicon dioxide, 10279-57-9, 14464-46-1, 14808-60-7, 15468-32-3, 60676-86-0, 7631-86-9 Subject BiologyAnalytical researchsilicon dioxideelectrochemical analysiselectrophoresiselectrospray mass spectrometrymicrochip analysismicrofluidic analysispositronpriority journalreviewChromatography, LiquidMicrofluidicsSpectrometry, Mass, Electrospray Ionization To reference this document use: http://resolver.tudelft.nl/uuid:daebcc97-ca02-4ad7-9f5e-d7473a938dbd DOI https://doi.org/10.1039/b709706a TNO identifier 240279 ISSN 1473-0197 Source Lab on a Chip - Miniaturisation for Chemistry and Biology, 7 (11), 1394-1412 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.