Title
A decade of microfluidic analysis coupled with electrospray mass spectrometry: An overview
Author
Koster, S.
Verpoorte, E.
TNO Kwaliteit van Leven
Publication year
2007
Abstract
This review presents a thorough overview covering the period 1997-2006 of microfluidic chips coupled to mass spectrometry through an electrospray interface. The different types of fabrication processes and materials used to fabricate these chips throughout this period are discussed. Three 'eras' of interfaces are clearly distinguished. The earliest approach involves spraying from the edge of a chip, while later devices either incorporate a standard fused-silica emitter inserted into the device or fully integrated emitters formed during chip fabrication. A summary of microfluidic-electrospray devices for performing separations and sample pretreatment steps before sample introduction into the mass spectrometer is also presented. © The Royal Society of Chemistry. Chemicals / CAS: silicon dioxide, 10279-57-9, 14464-46-1, 14808-60-7, 15468-32-3, 60676-86-0, 7631-86-9
Subject
Biology
Analytical research
silicon dioxide
electrochemical analysis
electrophoresis
electrospray mass spectrometry
microchip analysis
microfluidic analysis
positron
priority journal
review
Chromatography, Liquid
Microfluidics
Spectrometry, Mass, Electrospray Ionization
To reference this document use:
http://resolver.tudelft.nl/uuid:daebcc97-ca02-4ad7-9f5e-d7473a938dbd
DOI
https://doi.org/10.1039/b709706a
TNO identifier
240279
ISSN
1473-0197
Source
Lab on a Chip - Miniaturisation for Chemistry and Biology, 7 (11), 1394-1412
Document type
article