Meat consumption and K-ras mutations in sporadic colon and rectal cancer in The Netherlands Cohort Study

Meat consumption and K-ras mutations in sporadic colon and rectal cancer in The Netherlands Cohort Study

TNO Kwaliteit van Leven TNO Voeding
Brink, M.
Weijenberg, M.P.
de Goeij, A.F.P.M.
Roemen, G.M.J.M.
Lentjes, M.H.F.M.
de Bruïne, A.P.
Goldbohm, R.A.
van den Brandt, P.A.

2005

Case-cohort analyses were performed on meat and fish consumption in relation to K-ras mutations in 448 colon and 160 rectal cancers that occurred during 7.3 years of follow-up, excluding the first 2.3 years, and 2948 subcohort members of The Netherlands Cohort Study on diet and cancer. Adjusted incidence rate ratios and 95% confidence intervals were computed for colon and rectal cancer and for K-ras mutation status subgroups. Total fresh meat, most types of fresh meat and fish were not associated with colon or rectal cancer, neither overall nor with K-ras mutation status. However, several weak associations were observed for tumours with a wild-type K-ras, including beef and colon tumours, and an inverse association for pork with colon and rectal tumours; for meat products, an increased association was observed with wild-type K-ras tumours in the colon and possibly with G > A transitions in rectal tumours. © 2005 Cancer Research UK.

Food and Chemical Risk Analysis
Colon
Meat
Rectum
Wild-type K-ras
Nitrosamine
Polycyclic aromatic hydrocarbon
Cancer incidence
Cancer patient
Colon cancer
Dietary intake
Female
Gene mutation
Genetic heterogeneity
Genetic risk
Major clinical study
Rectum cancer
Wild type
Aged
Case-Control Studies
Cohort Studies
Colonic Neoplasms
Diet
DNA Mutational Analysis
Female
Genes, ras
Humans
Male
Meat
Meat Products
Middle Aged
Netherlands
Rectal Neoplasms
Risk Factors
Seafood

http://resolver.tudelft.nl/uuid:dacd81a3-dcf6-453f-95e2-d87fe566c255

https://doi.org/10.1038/sj.bjc.6602491

238433

0007-0920

British Journal of Cancer, 92 (92), 1310-1320

article