Title
Mannosylated PLP139-151 induces peptide-specific tolerance to experimental autoimmune encephalomyelitis
Author
Luca, M.E.
Kel, J.M.
van Rijs, W.
Drijfhout, J.W.
Koning, F.
Nagelkerken, L.
Gaubius Instituut TNO
Publication year
2005
Abstract
SJL mice immunized with mannosylated (M-) PLP139-151 in complete adjuvant do not develop EAE and little CNS mononuclear cell infiltration; other mannosylated peptides were ineffective in this experimental setting. Despite apparently normal T cell responses, M-PLP139-151-immunized mice show impaired delayed-type-sensitivity to PLP139-151 but a normal response to other peptides. After re-immunization with PLP139-151 in complete adjuvant, these mice are largely tolerant to EAE, show less T cell proliferation and decreased peptide-specific IgG2a. Our data suggest that M-PLP139-151 induces peptide-specific tolerance to EAE via a mechanism of deletion or impaired migration of encephalitogenic T cells. © 2004 Elsevier B.V. All rights reserved. Chemicals / CAS: Immunodominant Epitopes; Mannose, 31103-86-3; Myelin Proteolipid Protein; Peptide Fragments; proteolipid protein 139-151
Subject
C-type lectins
EAE
Mannose-receptor
Tolerance
immunoglobulin G2
myelin proteolipid protein[139-151]
proteolipid protein
unclassified drug
allergic encephalomyelitis
animal cell
animal experiment
animal model
animal tissue
cell migration
cell proliferation
controlled study
delayed hypersensitivity
drug effect
drug efficacy
female
immunization
mouse
nonhuman
priority journal
T lymphocyte
Amino Acid Sequence
Animals
Cell Movement
Cells, Cultured
Central Nervous System
Encephalomyelitis, Autoimmune, Experimental
Female
Hypersensitivity, Delayed
Immunodominant Epitopes
Injections, Subcutaneous
Leukocytes, Mononuclear
Mannose
Mice
Molecular Sequence Data
Myelin Proteolipid Protein
Peptide Fragments
Self Tolerance
Severity of Illness Index
Th1 Cells
To reference this document use:
http://resolver.tudelft.nl/uuid:d9600279-450c-4f82-b57d-5fb298374446
DOI
https://doi.org/10.1016/j.jneuroim.2004.11.014
TNO identifier
238383
ISSN
0165-5728
Source
Journal of Neuroimmunology, 160 (1-2), 178-187
Document type
article