Print Email Facebook Twitter Moderate alcohol consumption and lipoprotein-associated phospholipase A2 activity Title Moderate alcohol consumption and lipoprotein-associated phospholipase A2 activity Author Beulens, J.W.J. van den Berg, R. Kok, F.J. Helander, A. Vermunt, S.H.F. Hendriks, H.F.J. TNO Kwaliteit van Leven Publication year 2008 Abstract Background and aims: To investigate the effect of moderate alcohol consumption on lipoprotein-associated phospholipase A2 activity, markers of inflammation and oxidative stress and whether these effects are modified by BMI. Methods and results: Eleven lean (BMI: 18.5-25 kg/m2) and 9 overweight (BMI > 27 kg/m2) men participated in a randomized controlled crossover trial. After consuming 3 cans of beer (40 g ethanol) or alcohol-free beer daily during 3 weeks, fasting blood samples were taken. HDL cholesterol increased by 18.2% (p < 0.001) after beer compared to alcohol-free beer, while LDL cholesterol decreased by 7.8% (p = 0.008). Lipoprotein-associated phospholipase A2 activity was not different (p = 0.23) between beer (47.5 ± 0.8) and alcohol-free beer (48.9 ± 0.8). High-sensitive C-reactive protein was unaffected, but urinary isoprostanes tended to increase (p = 0.09) after beer (114.0 ± 6.9) compared to alcohol-free beer (96.9 ± 6.5). An interaction between BMI and treatment (p < 0.05) on liver enzymes was observed, indicating an increase of liver enzymes after moderate alcohol consumption in overweight men only. Conclusion: Despite profound effects on HDL and LDL cholesterol, moderate alcohol consumption did not affect lipoprotein-associated phospholipase A2 activity. Liver enzymes increased after alcohol consumption in overweight men only, suggesting a less favorable response to moderate alcohol consumption in overweight people. © 2007. Subject HealthBiomedical ResearchF2-isoprostanesLipoprotein-associated phospholipase A2Liver enzymesModerate alcohol consumptionObesityC reactive proteinHigh density lipoprotein cholesterolLow density lipoprotein cholesterolPhospholipase A2AdultAgedAlcohol abstinenceArticleBeerBloodBody weightCrossover procedureDrinking behaviorEnzymologyHumanMaleMetabolismObesityRandomizationAged, 80 and overAlcohol DrinkingBeerC-Reactive ProteinCholesterol, HDLCholesterol, LDLCross-Over StudiesHumansMaleOverweightPhospholipases A2Random AllocationTemperanceThinnessYoung Adult To reference this document use: http://resolver.tudelft.nl/uuid:d779d5ce-43f1-4a41-a4af-3e1ac30ae857 DOI https://doi.org/10.1016/j.numecd.2007.07.002 TNO identifier 241045 ISSN 0939-4753 Source Nutrition, Metabolism and Cardiovascular Diseases, 18 (8), 539-544 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.