Title
Moderate alcohol consumption and lipoprotein-associated phospholipase A2 activity
Author
Beulens, J.W.J.
van den Berg, R.
Kok, F.J.
Helander, A.
Vermunt, S.H.F.
Hendriks, H.F.J.
TNO Kwaliteit van Leven
Publication year
2008
Abstract
Background and aims: To investigate the effect of moderate alcohol consumption on lipoprotein-associated phospholipase A2 activity, markers of inflammation and oxidative stress and whether these effects are modified by BMI. Methods and results: Eleven lean (BMI: 18.5-25 kg/m2) and 9 overweight (BMI > 27 kg/m2) men participated in a randomized controlled crossover trial. After consuming 3 cans of beer (40 g ethanol) or alcohol-free beer daily during 3 weeks, fasting blood samples were taken. HDL cholesterol increased by 18.2% (p < 0.001) after beer compared to alcohol-free beer, while LDL cholesterol decreased by 7.8% (p = 0.008). Lipoprotein-associated phospholipase A2 activity was not different (p = 0.23) between beer (47.5 ± 0.8) and alcohol-free beer (48.9 ± 0.8). High-sensitive C-reactive protein was unaffected, but urinary isoprostanes tended to increase (p = 0.09) after beer (114.0 ± 6.9) compared to alcohol-free beer (96.9 ± 6.5). An interaction between BMI and treatment (p < 0.05) on liver enzymes was observed, indicating an increase of liver enzymes after moderate alcohol consumption in overweight men only. Conclusion: Despite profound effects on HDL and LDL cholesterol, moderate alcohol consumption did not affect lipoprotein-associated phospholipase A2 activity. Liver enzymes increased after alcohol consumption in overweight men only, suggesting a less favorable response to moderate alcohol consumption in overweight people. © 2007.
Subject
Health
Biomedical Research
F2-isoprostanes
Lipoprotein-associated phospholipase A2
Liver enzymes
Moderate alcohol consumption
Obesity
C reactive protein
High density lipoprotein cholesterol
Low density lipoprotein cholesterol
Phospholipase A2
Adult
Aged
Alcohol abstinence
Article
Beer
Blood
Body weight
Crossover procedure
Drinking behavior
Enzymology
Human
Male
Metabolism
Obesity
Randomization
Aged, 80 and over
Alcohol Drinking
Beer
C-Reactive Protein
Cholesterol, HDL
Cholesterol, LDL
Cross-Over Studies
Humans
Male
Overweight
Phospholipases A2
Random Allocation
Temperance
Thinness
Young Adult
To reference this document use:
http://resolver.tudelft.nl/uuid:d779d5ce-43f1-4a41-a4af-3e1ac30ae857
DOI
https://doi.org/10.1016/j.numecd.2007.07.002
TNO identifier
241045
ISSN
0939-4753
Source
Nutrition, Metabolism and Cardiovascular Diseases, 18 (8), 539-544
Document type
article