Print Email Facebook Twitter Body Mass Index and von Hippel-Lindau Gene Mutations in Clear-cell Renal Cancer: Results of the Netherlands Cohort Study on Diet and Cancer Title Body Mass Index and von Hippel-Lindau Gene Mutations in Clear-cell Renal Cancer: Results of the Netherlands Cohort Study on Diet and Cancer Author Smits, K.M. Schouten, L.J. Hudak, E. Verhage, B. van Dijk, B.A.C. van de Hulsbergen - Kaa, C.A. Goldbohm, R.A. Oosterwijk, E. van den Brandt, P.A. TNO Kwaliteit van Leven Publication year 2010 Abstract Purpose: Body mass index (BMI) is an important risk factor for clear-cell renal cancer (cc-RCC). A common molecular alteration in cc-RCC is loss-of-function of the von Hippel-Lindau (VHL) gene. We evaluated the association between BMI and VHL mutations in cc-RCC by using data from the Netherlands Cohort Study (NLCS), a prospective study, which comprises 120,852 persons. Methods: After 11.3 years of follow-up, 337 incident RCC cases were identified; 185 cc-RCC cases were included for analyses. Results: A high BMI at baseline was associated with an increased risk of cc-RCC with or without VHL mutations (per 1 kg/m2: hazard ratio [HR] = 1.09, 95% confidence interval [CI]: 1.02-1.16 and HR = 1.08, 95%CI: 1.01-1.15, respectively). BMI at age 20 was only associated with an increased risk of cc-RCC with VHL mutations (per 1 kg/m2: HR =1.09, 95% CI: 1.03-1.16). In contrast, BMI gain since age 20 was only associated with an increased risk in VHL wild-type cases (per 1 kg/m2: HR = 1.10, 95% CI: 1.03-1.19). Conclusion: Our findings indicate that BMI may be differently associated with subtypes of RCC based on VHL mutations. © 2010 Elsevier Inc. Subject HealthLeefomgeving en gezondheidBody Mass IndexClear-cell Renal CancerVHL Mutationsvon Hippel Lindau proteinadultagearticlebody masscancer riskclear cell carcinomacohort analysiscontrolled studydietfemalegene mutationhumankidney cancermajor clinical studymaleNetherlandspriority journalprospective studyrisk factorweight gainwild typeAdultBody Mass IndexCarcinoma, Renal CellCohort StudiesConfidence IntervalsDietFemaleHumansKidney NeoplasmsMaleMiddle AgedMutationNetherlandsNutritional StatusRisk Factorsvon Hippel-Lindau DiseaseYoung Adult To reference this document use: http://resolver.tudelft.nl/uuid:d75198dc-79fe-493f-88a8-5a31ca17686c TNO identifier 408477 ISSN 1047-2797 Source Annals of Epidemiology, 20 (5), 401-404 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.