Title
Acute release of tissue-type plasminogen activator (t-PA) from the endothelium ; regulatory mechanisms and therapeutic target
Author
Schrauwen, Y.
de Vries, R.E.M.
Kooistra, T.
Emeis, J.J.
TNO Preventie en Gezondheid
Publication year
1994
Abstract
The acute release of t-PA was studied in vitro in human endothelial cells from different origin. It proved possible to enhance the amounts of t-PA which can be released by increasing t-PA synthesis, both in vitro, and in vivo in rats. These data suggest the feasibility to induce and (or) enhance acute release of t-PA in man. Chemicals/CAS: bradykinin, 58-82-2, 5979-11-3; butyric acid, 107-92-6, 156-54-7, 461-55-2; retinoic acid, 302-79-4; thrombin, 9002-04-4; tissue plasminogen activator, 105913-11-9
Subject
Biology
endothelium
fibrinolysis
regulated secretion
tissue-type plasminogen activator (t-PA)
bradykinin
butyric acid
cholera toxin
retinoic acid
thrombin
tissue plasminogen activator
animal cell
animal experiment
conference paper
endothelium cell
fibrinolysis
protein secretion
rat
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TNO identifier
232417
ISSN
0268-9499
Source
Fibrinolysis, 8 (SUPPL. 2), 8-12
Document type
article