Extractant selection strategy for solvent-impregnated resins in fermentations
van den Berg, C.
van der Wielen, L.
TNO Kwaliteit van Leven TNO Separation Technolog
The application of extractants in whole-cell biocatalysis can have a positive impact on industrial fermentations, in terms of productivity, total amount of product produced, and cell growth. When a product is continuously removed from the microorganism surroundings, product inhibition will be diminished. The strategy is exemplified using phenol as the product and the extractant is selected for solvent-impregnated resins, which can prevent emulsification problems that are commonly encountered in in situ extractive recovery of fermentation products. A systematic approach for selection of superior extractants in whole-cell biocatalysis is discussed in this paper. Three criteria are taken into account, namely, extractant toxicity (log P o/w values), product selectivity, and extractant regeneration. ©2008 American Chemical Society.
To reference this document use:
Industrial and Engineering Chemistry Research, 47 (24), 10071-10075