Print Email Facebook Twitter New reference charts for testicular volume in Dutch children and adolescents allow the calculation of standard deviation scores Title New reference charts for testicular volume in Dutch children and adolescents allow the calculation of standard deviation scores Author Joustra, S.D. van der Plas, E.M. Goede, J. Oostdijk, W. Delemarre-van de Waal, H.A. Hack, W.W.M. van Buuren, S. Wit, J.M. Publication year 2015 Abstract Aim Accurate calculations of testicular volume standard deviation (SD) scores are not currently available. We constructed LMS-smoothed age-reference charts for testicular volume in healthy boys. Methods The LMS method was used to calculate reference data, based on testicular volumes from ultrasonography and Prader orchidometer of 769 healthy Dutch boys aged 6 months to 19 years. We also explored the association between testicular growth and pubic hair development, and data were compared to orchidometric testicular volumes from the 1997 Dutch nationwide growth study. Results The LMS-smoothed reference charts showed that no revision of the definition of normal onset of male puberty - from nine to 14 years of age - was warranted. In healthy boys, the pubic hair stage SD scores corresponded with testicular volume SD scores (r = 0.394). However, testes were relatively small for pubic hair stage in Klinefelter's syndrome and relatively large in immunoglobulin superfamily member 1 deficiency syndrome. Conclusion The age-corrected SD scores for testicular volume will aid in the diagnosis and follow-up of abnormalities in the timing and progression of male puberty and in research evaluations. The SD scores can be compared with pubic hair SD scores to identify discrepancies between cell functions that result in relative microorchidism or macroorchidism. ©2015 Foundation Acta Pædiatrica. Published by John Wiley & Sons Ltd. Subject LifeLS - Life StyleELSS - Earth, Life and Social SciencesHealthy for LifeHealthHealthy LivingLMSOrchidometerReference valuesTestisUltrasonographyImmunoglobulinAdolescentCalculationChildEchographyGrowth curveHair growthImmunoglobulin deficiencyImmunoglobulin superfamily member 1 deficiency syndromeInfantKlinefelter syndromeLms smoothed age reference chartMaleNormal humanOrgan growthPubertyTestis size To reference this document use: http://resolver.tudelft.nl/uuid:d4950ade-ac2b-4bd3-90ff-9cb2a7a59cd9 DOI https://doi.org/10.1111/apa.12972 TNO identifier 526104 ISSN 0803-5253 Source Acta Paediatrica, International Journal of Paediatrics, 104 (6), e271-e278 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.