Title
Degree of synovitis on MRI by comprehensive whole knee semi-quantitative scoring method correlates with histologic and macroscopic features of synovial tissue inflammation in knee osteoarthritis
Author
de Lange-Brokaar, B.J.E.
Ioan-Facsinay, A.
Yusuf, E.
Visser, A.W.
Kroon, H.M.
Andersen, S.N.
Herb-van Toorn, L.
van Osch, G.J.V.M.
Zuurmond, A.M.
Stojanovic-Susulic, V.
Bloem, J.L.
Nelissen, R.G.H.H.
Huizinga, T.W.J.
Kloppenburg, M.
Publication year
2014
Abstract
Objective: To evaluate the association between synovitis on contrast enhanced (CE) MRI with microscopic and macroscopic features of synovial tissue inflammation. Method: Forty-one patients (mean age 60 years, 61% women) with symptomatic radiographic knee OA were studied: twenty underwent arthroscopy (macroscopic features were scored (0-4), synovial biopsies obtained), twenty-one underwent arthroplasty (synovial tissues were collected). After haematoxylin and eosin staining, the lining cell layer, synovial stroma and inflammatory infiltrate of synovial tissues were scored (0-3). T1-weighted CE-MRI's (3T) were used to semi-quantitatively score synovitis at 11 sites (0-22) according to Guermazi etal. Spearman's rank correlations were calculated. Results: The mean (SD) MRI synovitis score was 8.0 (3.7) and the total histology grade was 2.5 (1.6). Median (range) scores of macroscopic features were 2 (1-3) for neovascularization, 1 (0-3) for hyperplasia, 2 (0-4) for villi and 2 (0-3) for fibrin deposits.The MRI synovitis score was significantly correlated with total histology grade [. r=0.6], as well as with lining cell layer [. r=0.4], stroma [. r=0.3] and inflammatory infiltrate [. r=0.5] grades. Moreover, MRI synovitis score was also significantly correlated with macroscopic neovascularization [. r=0.6], hyperplasia [. r=0.6] and villi [. r=0.6], but not with fibrin [. r=0.3]. Conclusion: Synovitis severity on CE-MRI assessed by a new whole knee scoring system by Guermazi etal. is a valid, non-invasive method to determine synovitis as it is significantly correlated with both macroscopic and microscopic features of synovitis in knee OA patients. Chemicals/CAS: gadolinium, 7440-54-2 Tradenames: dotaremPhilips Achieva, Philips, Netherlands
Subject
Life
MHR - Metabolic Health Research
ELSS - Earth, Life and Social Sciences
Biomedical Innovation
Biology
Healthy Living
Macroscopy
MRI
Osteoarthritis
Synovial tissue
Synovitis
Gadolinium
Adult
Clinical article
Correlational study
Female
Fibrin deposition
Histology tissue
Hyperplasia
Joint biopsy
Kellgren Lawrence scale
Knee arthroplasty
Knee arthroscopy
Knee osteoarthritis
Male
Microscopy
Named inventories, questionnaires and rating scales
Neovascularization (pathology)
Nuclear magnetic resonance imaging
Nuclear magnetic resonance scanner
Observational study
Outcome assessment
Pain severity
Radiological parameters
Synovitis
Synovium
Visual analog scale
X ray film
To reference this document use:
http://resolver.tudelft.nl/uuid:d43bedea-fef6-45c0-810f-6db53b15fe4b
DOI
https://doi.org/10.1016/j.joca.2013.12.013
TNO identifier
519619
ISSN
1063-4584
Source
Osteoarthritis and Cartilage, 22 (10), 1606-1613
Document type
article