Print Email Facebook Twitter Workshop overview: Approaches to the assessment of the allergenic potential of food from genetically modified crops Title Workshop overview: Approaches to the assessment of the allergenic potential of food from genetically modified crops Author Ladics, G.S. Holsapple, M.P. Astwood, J.D. Kimber, I. Knippels, L.M.J. Helm, R.M. Dong, W. Publication year 2003 Abstract There is a need to assess the safety of foods deriving from genetically modified (GM) crops, including the allergenic potential of novel gene products. Presently, there is no single in vitro or in vivo model that has been validated for the identification or characterization of potential food allergens. Instead, the evaluation focuses on risk factors such as source of the gene (i.e., allergenic vs. nonallergenic sources), physicochemical and genetic comparisons to known allergens, and exposure assessments. The purpose of this workshop was to gather together researchers working on various strategies for assessing protein allergenicity: (1) to describe the current state of knowledge and progress that has been made in the development and evaluation of appropriate testing strategies and (2) to identify critical issues that must now be addressed. This overview begins with a consideration of the current issues involved in assessing the allergenicity of GM foods. The second section presents information on in vitro models of digestibility, bioinformatics, and risk assessment in the context of clinical prevention and management of food allergy. Data on rodent models are presented in the next two sections. Finally, nonrodent models for assessing protein allergenicity are discussed. Collectively, these studies indicate that significant progress has been made in developing testing strategies. However, further efforts are needed to evaluate and validate the sensitivity, specificity, and reproducibility of many of these assays for determining the allergenicity potential of GM foods. Subject Biology HealthToxicology and Applied Pharmacologyallergenfood allergengene productallergenicityallergic reactionbioinformaticsdigestionexposurefood allergyfood safetygenetic analysisgenetically modified crophumanhypersensitivity reactionin vitro studyin vivo studymedical researchnonhumannucleotide sequencephysical chemistryprick testreproducibilityreviewrisk assessmentrisk factorvalidation processworkshopAnimalsDisease Models, AnimalFood HypersensitivityFood, Genetically ModifiedMiceMice, Inbred BALB CPlant ProteinsRatsRats, Inbred BNRodentia To reference this document use: http://resolver.tudelft.nl/uuid:d2a8f166-5aff-4ebe-959a-cf99b3aace26 DOI https://doi.org/10.1093/toxsci/kfg055 TNO identifier 237068 ISSN 1096-6080 Source Toxicological Sciences, 73 (1), 8-16 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.