Workshop overview: Approaches to the assessment of the allergenic potential of food from genetically modified crops

Workshop overview: Approaches to the assessment of the allergenic potential of food from genetically modified crops

Ladics, G.S.
Holsapple, M.P.
Astwood, J.D.
Kimber, I.
Knippels, L.M.J.
Helm, R.M.
Dong, W.

2003

There is a need to assess the safety of foods deriving from genetically modified (GM) crops, including the allergenic potential of novel gene products. Presently, there is no single in vitro or in vivo model that has been validated for the identification or characterization of potential food allergens. Instead, the evaluation focuses on risk factors such as source of the gene (i.e., allergenic vs. nonallergenic sources), physicochemical and genetic comparisons to known allergens, and exposure assessments. The purpose of this workshop was to gather together researchers working on various strategies for assessing protein allergenicity: (1) to describe the current state of knowledge and progress that has been made in the development and evaluation of appropriate testing strategies and (2) to identify critical issues that must now be addressed. This overview begins with a consideration of the current issues involved in assessing the allergenicity of GM foods. The second section presents information on in vitro models of digestibility, bioinformatics, and risk assessment in the context of clinical prevention and management of food allergy. Data on rodent models are presented in the next two sections. Finally, nonrodent models for assessing protein allergenicity are discussed. Collectively, these studies indicate that significant progress has been made in developing testing strategies. However, further efforts are needed to evaluate and validate the sensitivity, specificity, and reproducibility of many of these assays for determining the allergenicity potential of GM foods.

Biology Health
Toxicology and Applied Pharmacology
allergen
food allergen
gene product
allergenicity
allergic reaction
bioinformatics
digestion
exposure
food allergy
food safety
genetic analysis
genetically modified crop
human
hypersensitivity reaction
in vitro study
in vivo study
medical research
nonhuman
nucleotide sequence
physical chemistry
prick test
reproducibility
review
risk assessment
risk factor
validation process
workshop
Animals
Disease Models, Animal
Food Hypersensitivity
Food, Genetically Modified
Mice
Mice, Inbred BALB C
Plant Proteins
Rats
Rats, Inbred BN
Rodentia

http://resolver.tudelft.nl/uuid:d2a8f166-5aff-4ebe-959a-cf99b3aace26

https://doi.org/10.1093/toxsci/kfg055

237068

1096-6080

Toxicological Sciences, 73 (1), 8-16

article