Title
Changes in local cerebral blood flow, local EEG, and flow in the distal stump of the middle cerebral artery in cats with occlusion of the middle cerebral artery
Author
Tulleken, C.A.F.
van Dieren, A.
ten Veen, J.
Lopes Da Silva, F.H.
TNO Workgroup Clin. Neurophysiol., Westeinde Hosp., The Hague, Netherlands Medisch Biologisch Laboratorium TNO
Publication year
1982
Abstract
The local EEG, the local cerebral blood flow (lCBF), and the flow in the distal stump of the occluded middle cerebral artery were simultaneously recorded in 28 acute experiments in cats. Nembutal anesthesia was used eleven times, and Halothane anaesthesia 17 times. The recordings were made via platinum electrodes: 12 in the ischaemic hemisphere, and 2-3 in the opposite non-ischaemic hemisphere. The flow in the occluded middle cerebral artery was recorded via a platinum electrode introduced into this artery via the transorbital approach. The changes in lEEG, lCBF, and middle cerebral artery flow were studied during normotension, hypertension, and hypotension. A beneficial effect of hypertension was noted in the acute phase of brain ischaemia. Hypertension counteracted also the 'diaschisis' in the non-ischaemic part of the ischaemic hemisphere and in the opposite non-ischaemic hemisphere. A correlation between lEEG changes and lCBF changes were noted. In addition an interesting discrepancy was observed between the rapid H2 clearance in the middle cerebral artery stump and the much slower H2 clearance in the ischaemic brain area. Significant differences between experiments under Halothane and experiments under Nembutal anaesthesia were noted. In the acute phase those changes are probably the result of the different levels of blood pressure in those two groups. Chemicals/CAS: Metaraminol, 54-49-9; Nitroprusside, 15078-28-1
Subject
Health
Radioisotope
Animal experiment
Blood pressure
Cardiovascular system
Cat
Central nervous system
Electroencephalography
Middle cerebral artery
Peripheral vascular system
Animal
Arterial Occlusive Diseases
Cats
Cerebral Arteries
Cerebrovascular Circulation
Electrodes, Implanted
Electroencephalography
Female
Homeostasis
Hypertension
Hypotension
Male
Metaraminol
Nitroprusside
Regional Blood Flow
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TNO identifier
280728
ISSN
0001-6268
Source
Acta Neurochirurgica, 61 (1-3), 227-240
Document type
article