Print Email Facebook Twitter Activation of inapparent infection with ectromelia and pneumonia virus in mice Title Activation of inapparent infection with ectromelia and pneumonia virus in mice Author Nederlands Instituut voor Praeventieve Gezondheidszorg TNO Verlinde, J.D. Winsser, J. Publication year 1949 Abstract In mice used for the adaptation of a strain of influenza A virus, peculiar lunglesions, differing from influenza lesions, were found. Afterwards cases of ectromelia were observed in the same mouse colony, and the ectromelia virus was demonstrated in the clinically manifest cases as well as in the lunglesions of apparently normal mice that died after intranasal instillation of influenza virus. A few years later mice from a different colony were used for influenza B virus adaptation and in attempts to demonstrate a virus in the blood and throat washings of persons suffering from an acute respiratory disease, which prevailed in a rural municipality. In a number of mice that had been infected intranasally with influenza B virus, and with defibrinated blood and throat washings of patients, a pneumonia developed after some blind passages, which appeared to be caused by the mouse pneumonia virus. 10.4 per cent of apparently normal mice in the colony proved to be carriers of the virus. The causative agent of the epidemic in the village could not be detected. In convalescent as well as in acute phase and in normal sera from persons in a different region, neutralizing antibodies against the mouse pneumonia virus could be demonstrated. © 1949 Swets en Zeitlinger. Subject PneumoniaVirusMiceInfection To reference this document use: http://resolver.tudelft.nl/uuid:cfd3e9bf-60b6-4e1b-9d90-8ae37d9daf0c DOI https://doi.org/10.1007/bf02062630 TNO identifier 946767 ISSN 0003-6072 Source Antonie van Leeuwenhoek, 15 (15), 41-48 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.