Title
Dietary iron and risk of myocardial infarction in the Rotterdam Study
Author
Klipstein-Grobusch, K.
Grobbee, D.E.
den Breeijen, J.H.
Boeing, H.
Hofman, A.
Witteman, J.C.M.
Publication year
1999
Abstract
Free iron has been implicated in lipid peroxidation and ischemic myocardial damage, and it has been suggested that iron is an independent risk factor for myocardial infarction. The authors investigated whether dietary iron is associated with an increased risk of fatal and nonfatal myocardial infarction in the Rotterdam Study, a community-based prospective cohort study of 7,983 elderly subjects in Rotterdam, the Netherlands. The study sample consisted of 4,802 participants who at baseline had no known history of myocardial infarction and for whom dietary data were available. From 1990 to 1996, 124 subjects had a myocardial infarction. No association was observed between total iron intake and risk of myocardial infarction after adjustment for age and sex (relative risk for the highest vs. the lowest tertile of intake=0.89, 95% confidence interval (CI) 0.55-1.45, p for trend=0.640). Heme iron intake was positively associated with risk of myocardial infarction (relative risk for the highest vs. the lowest tertile of intake=1.83, 95% Cal 1.16-2.91, p for trend=0.008) after adjustment for age and sex, and this association persisted after multivariate adjustment (relative risk=1.86, 95% Cal 1.14-3.09, p for trend=0.010). A distinction between fatal and nonfatal cases of myocardial infarction indicated that the association of heme iron with myocardial infarction was more pronounced in fatal cases. The results suggest that a high dietary heme iron intake is related to an increased risk of myocardial infarction and that it may specifically affect the rate of fatality from myocardial infarction.
Subject
Coronary disease
Dietary
Elderly
Iron
Myocardial infarction
iron
low density lipoprotein cholesterol
aged
article
cardiovascular risk
clinical study
disease association
fatality
follow up
heart infarction
heart muscle ischemia
human
iron intake
lipid peroxidation
major clinical study
risk assessment
risk factor
Diet
Diet Surveys
Female
Humans
Iron, Dietary
Male
Middle Aged
Multivariate Analysis
Myocardial Infarction
Netherlands
Prospective Studies
Questionnaires
Risk Factors
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TNO identifier
234972
ISSN
0002-9262
Source
American Journal of Epidemiology, 149 (5), 421-428
Document type
article