Title
CD40 in clinical inflammation: From multiple sclerosis to atherosclerosis
Author
Laman, J.D.
de Boer, M.
't Hart, B.A.
TNO Preventie en Gezondheid
Publication year
1998
Abstract
The interactions of CD40 and CD40L have been known for some time to critically regulate B-cell responses with respect to proliferation, isotype switching, antibody production, and memory formation. More recent findings demonstrated that CD40 can be expressed on several other antigen-presenting cell (APC) types such as macrophages, dendritic cells, and fibroblasts. This expression of CD40 regulates T-cell-APC interaction and is centrally involved in a wide array of inflammatory events. Here, currently available data are reviewed demonstrating that CD40-CD40L interactions are operational in two chronic inflammatory clinical conditions, namely, multiple sclerosis and atherosclerosis. The functional correlates of these interactions are discussed in the light of recent other findings, shedding light on the multiple effects of CD40-CD40L interactions.
Subject
Health
Accessory molecules
Costimulation
Immunocytochemistry
Macrophages
Animals
Antigen-Presenting Cells
Antigens, CD40
Arteriosclerosis
CD40 Ligand
Encephalomyelitis, Autoimmune, Experimental
Humans
Membrane Glycoproteins
Multiple Sclerosis
T-Lymphocytes
To reference this document use:
http://resolver.tudelft.nl/uuid:ce567813-05f1-4466-b7f1-82b1d8adcf91
TNO identifier
234680
ISSN
1044-6672
Source
Developmental Immunology, 6 (3-4), 215-222
Document type
article