Print Email Facebook Twitter Hyperplasia of the lymphoepithelium of NALT in rats but not in mice upon 28-day exposure to 15ppm formaldehyde vapor Title Hyperplasia of the lymphoepithelium of NALT in rats but not in mice upon 28-day exposure to 15ppm formaldehyde vapor Author Kuper, C.F. van Oostrum, L. Ma-Hock, L. Durrer, S. Woutersen, R.A. Publication year 2011 Abstract To investigate if local lymphoid tissues are a target of FA, nasopharynx-associated lymphoid tissues (NALT) and upper-respiratory tract-draining lymph nodes were examined in a 28-day inhalation study with FA vapor in Fischer-344 rats and B6C3F1 mice.Paraffin-embedded tissues were sectioned and stained with H&E or stained immunohistochemically for cell proliferation (BrdU incorporation).Light microscopy revealed simple hyperplasia of NALT lymphoepithelium of rats exposed to 15. ppm and an increased proliferation rate of the epithelial cells. Principal component (discriminant) analysis of rat NALT and lymph nodes data did not reveal other effects or effects at lower exposure levels. Mice tissues were not affected.It was concluded that hyperplasia of the lymphoepithelium of NALT of rats exposed to 15. ppm was the only distinct effect of FA vapor on local lymphoid tissues (NALT and lymph nodes) of Fischer-344 rats and B3C3F1 mice. © 2009 Elsevier GmbH. Subject LifeQS - Quality & SafetyEELS - Earth, Environmental and Life SciencesNutritionBrdUCervical lymph nodesHyperplasiaLymphoepitheliumPCA To reference this document use: http://resolver.tudelft.nl/uuid:cc165903-76a8-4319-b316-2cd75ade4354 DOI https://doi.org/10.1016/j.etp.2009.09.004 TNO identifier 426092 ISSN 0940-2993 Source Experimental and Toxicologic Pathology, 63 (1-2), 25-32 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.