Print Email Facebook Twitter Positive association between the course of vitamin D intake and bone mineral density at 36 years in men Title Positive association between the course of vitamin D intake and bone mineral density at 36 years in men Author van Dijk, C.E. de Boer, M.R. Koppes, L.L.J. Roos, J.C. Lips, P. Twisk, J.W.R. TNO Kwaliteit van Leven Publication year 2009 Abstract Introduction: Studies on the association of vitamin D and bone mineral density (BMD) in adolescence and young adults have shown contrasting results. None of these studies have examined the course and baseline in vitamin D intake. The purpose of this study was to examine the association between baseline and the course of dietary vitamin D intake on the BMD. Methods: Vitamin D intake was assessed 3-8 times between the age of 13 and 36 years in 152 men and 168 women from the Amsterdam Growth and Health Longitudinal Study. The BMD of the femoral neck, lumbar spine, total hip and total body was measured at the age of 36 years with dual-energy X-ray absorptiometry. Linear regression analyses were used to determine the vitamin D intake pattern in time for each subject. The models provide a baseline, course and fluctuation of the vitamin D intake for each subject. These were used in separate regression analyses with the dependent variable BMD. Results: Mean baseline vitamin D was 6.86 (SD: 2.18) μg/day for men and 4.90 (1.19) μg/day for women. Mean course of vitamin D was - 0.10 (0.12) μg/day/year and - 0.05 (0.18) μg/day/year for men and women respectively. After adjustment for potential confounders and correcting for the other parameters of vitamin D intake, the associations between baseline vitamin D intake and BMD were significant in the total hip (0.018 g/cm2 per - 1 μg/day; 95% CI 0.001-0.035) and total body (0.015 per - 1 μg/day; 0.001-0.029). The course of vitamin D intake was associated with BMD in the lumbar spine (0.50 g/cm2 per - 1 μg/day/year; 0.130-0.867), femoral neck (0.42 g/cm2 per - 1 μg/day/year; 0.10-0.743), total body (0.34 g/cm2 per - 1 μg/day/year; 0.09-0.59) and total hip (0.44 g/cm2 per - 1 μg/day/year; 0.11-0.77) in men. No significant associations were found in women. Conclusion: In men, the level of vitamin D intake in adolescence and the course of vitamin D intake from adolescence into adulthood are positively related with BMD in adulthood. In women, however, no significant associations are found. © 2008 Elsevier Inc. All rights reserved. Subject WorkplaceVeilig en Gezond WerkenBone mineral densityLongitudinalNutritionVitamin DYoung adultsvitamin Dadolescentadultarticlebone densitycontrolled studydietary intakedual energy X ray absorptiometryfemalefollow uphumanlumbar spinemalesex differencevitamin blood levelvitamin intakeAbsorptiometry, PhotonAdolescentAdultBone DensityDietary SupplementsFemaleHumansMaleOsteoporosisRegression AnalysisVitamin DYoung Adult To reference this document use: http://resolver.tudelft.nl/uuid:cb97a5c9-9a4f-4ddb-87cb-5d6908d2b6df DOI https://doi.org/10.1016/j.bone.2008.10.055 TNO identifier 241432 ISSN 8756-3282 Source Bone, 44 (3), 437-441 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.