Dietary selenium, selenium status, fat consumption and body composition: A case-control study on the etiology of pre- and postmenopausal breast cancer
van 't Veer, P.
van Faassen, A.
Instituut CIVO-Toxicologie en Voeding TNO
Joossens, J.V. (editor)
Dìet is considered to be a potentiaì1y modifiabìe exposure which mìght give opportunities to reduce breast cancer incidence (l ). It is, however, not known whìch specìfic factors are the most important causes of breast cancer in the Netherlands. Results of correlation studies suggest that the relatìveìy high Dutch breast cancer incidence and mortality (2) mìght be expìained by the high per capita fat intake (3) and the presumabìy low selenium intake (4). These associations are al so demonstrated in animal studies (5). Up to now, case-control sttudies on diet and breast cancer have mainly focused on animal products (6) or dietary fat (6-8) and consumption of alcoholic beverages (9-ll). Also, in two cohort studies (12,13) positive associations with animal products and fat-containing foods were found, while several Japanese foodstuffs were negatively associated. These dìetary components are thought to promote neoplastic disease. 0n the other hand, selenium is suggested to be a protective agent against cancer ìn generaì (14). Case-control studies showed contradictory results in blood selenium levels between breast cancer cases and controls (15,16). Two recent prospectìve studies have reported an inverse relation between a low prediagnostrc selenium level and subsequent (all sites) cancer risk (14,17). 1n general, however, these studies were small and site specific analyses could not be studied wìth much statistical power (14,l8). Also, a protective effect has been found of increased blood levels of vitamin t, possibly of ß-carotene, but not of serum retinol (l9).
To reference this document use:
Diet and human carcinogenesis, 207-212