Title
Ultrastructure of hepatic angiosarcoma in rats induced by vinyl chloride
Author
Spit, B.J.
Feron, V.J.
Hendriksen, C.F.M.
Centraal Instituut voor Voedingsonderzoek TNO
Publication year
1981
Abstract
The hepatic angiosarcoma studied was from a male Wistar rat having been exposed to vinyl chloride monomer (VCM) by the oral route for 120 weeks. Widened sinusoids lined by large electron-lucent, spindle-shaped tumor cells and membrane-bound nuclear-free structures were seen in the transitional zone between the tumor mass and the adjacent liver tissue. In areas merely consisting of tumor tissue the tumor cells had a more angular or irregular shape. The origin of the tumor cells is discussed in light of the characteristic differences between endothelial cells and Kupffer cells described in the literature. Although an endothelial origin of the tumor cells could not be established unequivocally, it was concluded that at present there is little reason to doubt such an origin. Chemicals/CAS: vinyl chloride, 75-01-4; Vinyl Chloride, 75-01-4
Subject
Vinyl chloride
Adverse drug reaction
Angiosarcoma
Animal experiment
Carcinogenesis
Electron microscopy
Liver
Liver cancer
Oral drug administration
Rat
Animal
Hemangiosarcoma
Liver Neoplasms
Male
Microscopy, Electron
Rats
Rats, Inbred Strains
Sarcoma, Experimental
Support, Non-U.S. Gov't
Vinyl Chloride
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TNO identifier
229045
ISSN
0014-4800
Source
Experimental and Molecular Pathology, 35 (2), 277-284
Document type
article