Title
Animal model of human disease. Multiple myeloma
Author
Radl, J.
Croese, J.W.
Zurcher, C.
van den Enden-Vieveen, M.H.M.
de Leeuw, A.M.
Instituut voor Experimentele Gerontologie TNO
Publication year
1988
Abstract
Animal models of spontaneous and induced plasmacytomas in some inbred strains of mice have proven to be useful tools for different studies on tumorigenesis and immunoregulation. Their wide applicability and the fact that after their intravenous transplantation, the recipient mice developed bone lesions, led in some instances to an incorrect use of the term myeloma for these neoplasms. They originate and grow as extramedullary plasmacytomas, mostly without involvement of the bone marrow. Therefore, they cannot be compared with the most frequent plasma cell malignancy in humans, the multiple myeloma (MM). A more appropriate model for MM is available in aging mice of the C57BL/KaLwRij strain.
Subject
Health
animal cell
animal experiment
animal model
histochemistry
histology
immunocytoma
multiple myeloma
nonhuman
plasmacytoma
Aging
Animal
Disease Models, Animal
Human
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Multiple Myeloma
Support, U.S. Gov't, P.H.S.
To reference this document use:
http://resolver.tudelft.nl/uuid:c908c2f0-df84-4325-ba5d-463c6cd52873
TNO identifier
230628
ISSN
0002-9440
Source
American Journal of Pathology, 132 (3), 593-597
Document type
article