Title
Acquiring and maintaining a normal oral microbiome: Current perspective.
Author
Zaura, E.
Nicu, E.A.
Krom, B.P.
Keijser, B.J.
Publication year
2014
Abstract
The oral microbiota survives daily physical and chemical perturbations from the intake of food and personal hygiene measures, resulting in a long-term stable microbiome. Biological properties that confer stability in the microbiome are important for the prevention of dysbiosis-a microbial shift toward a disease, e.g., periodontitis or caries. Although processes that underlie oral diseases have been studied extensively, processes involved in maintaining of a normal, healthy microbiome are poorly understood. In this review we present our hypothesis on how a healthy oral microbiome is acquired and maintained. We introduce our view on the prenatal development of tolerance for the normal oral microbiome: we propose that development of fetal tolerance toward the microbiome of the mother during pregnancy is the major factor for a successful acquisition of a normal microbiome. We describe the processes that influence the establishment of such microbiome, followed by our perspective on the process of sustaining a healthy oral microbiome. We divide microbiome-maintenance factors into host-derived and microbe-derived, while focusing on the host. Finally, we highlight the need and directions for future research.
Subject
Life
MSB - Microbiology and Systems Biology
ELSS - Earth, Life and Social Sciences
Biomedical Innovation
Biology
Healthy Living
Colonization resistance
Microbiology
Microflora
Mouth
Mucosal immunity
Oral microbiome
Placenta
Pregnancy
Review
Stability
Tolerance
Colonization resistance
Mucosal immunity
Oral microbiome
Microbiota
To reference this document use:
http://resolver.tudelft.nl/uuid:c8d066ce-ac86-4553-90b0-5ff67044a10b
TNO identifier
516469
ISSN
2235-2988
Source
Frontiers in cellular and infection microbiology, 4, 85
Document type
article