Print Email Facebook Twitter A moderate fish intake increases plasminogen activator inhibitor type-1 in human volunteers Title A moderate fish intake increases plasminogen activator inhibitor type-1 in human volunteers Author Emeis, J.J. van Houwelingen, A.C. van den Hoogen, C.M. Hornstra, G. Gaubius Institute TNO, 2300 AP Leiden, Netherlands Publication year 1989 Abstract For a period of 6 weeks, 76 healthy male volunteers consumed during their daily main meal the contents of one tin (~ 135 g) of either fish (mackerel) paste or meat paste. Fibrinolytic parameters were determined in plasma samples obtained at the beginning and at the end of the experimental period. No changes were found in plasminogen, α2-antiplasmin, tissue-type plasminogen activator (t-PA) antigen, and euglobulin t-PA activity. In the control group (n = 39), plasminogen activator inhibitor activity did not change. In the fish group (n = 37), however, total plasma PA inhibitor (PAI) activity increased by 45%, due to a 71% increase in PA inhibitor type-1. This increase could not be ascribed to a diet-induced acute phase-type reaction and could not be explained by changes in serum triglycerides or insulin. Chemicals/CAS: plasminogen activator inhibitor 1, 140208-23-7; Acute-Phase Proteins; Glycoproteins; Plasminogen Activators, EC 3.4.21.-; Plasminogen Inactivators Subject Plasminogen activator inhibitor 1Controlled studyDrug efficacyHuman experimentNormal humanAcute-Phase ProteinsAdultAnimalDietFibrinolysisFishesGlycoproteinsHumanMaleMeatPlasminogen ActivatorsPlasminogen InactivatorsSupport, Non-U.S. Gov'tTime Factors To reference this document use: http://resolver.tudelft.nl/uuid:c8cb1ed1-68b7-4d3e-9a32-7971a068e416 TNO identifier 230821 ISSN 0006-4971 Source Blood, 74 (1), 233-237 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.