Print Email Facebook Twitter Kinetics of homocysteine metabolism after moderate alcohol consumption Title Kinetics of homocysteine metabolism after moderate alcohol consumption Author Beulens, J.W.J. Sierksma, A. Schaafsma, G. Kok, F.J. Struys, E.A. Jakobs, C. Hendriks, H.F.J. TNO Kwaliteit van Leven Publication year 2005 Abstract Background: Moderate alcohol consumption is associated with a decreased risk of cardiovascular disease. Because plasma homocysteine (tHcy) is considered an independent risk factor for cardiovascular disease and associated with alcohol consumption, the authors investigated the effect of moderate alcohol consumption on kinetics of plasma tHcy concentration, vitamin B status, and other parameters involved in tHcy metabolism. Methods: Ten healthy men and nine healthy postmenopausal women (aged 45-65 years) participated in a randomized, diet-controlled, crossover trial. They consumed beer or alcohol-free beer (men: 4 units/day; women: 3 units/day) during 3 weeks, separated by a 1-week washout. On days 5, 10, 15, and 20 of each period, fasting blood samples were taken. Results: Plasma tHcy (μM) and S-adenosyl methionine/S-adenosyl homocysteine ratio were not affected by consumption of beer or alcohol-free beer (p = 0.33 and p = 0.14, respectively). Plasma pyridoxal-5-phosphate (μg/liter) increased during consumption of beer (+11.0%), whereas it decreased during consumption of alcohol-free beer (-34.0%; p = 0.042). Changes over time of plasma vitamin B6 (μg/liter) were similar to changes in plasma pyridoxal-5-phosphate (p = 0.10). Serum vitamin B12 was higher (p < 0.001) after 3 weeks consumption of alcohol-free beer (382.8 ± 23.7 pg/liter) as compared with beer consumption (327.5 ± 22.2 pg/liter). Changes in serum methionine, cysteine, cystathionine, and plasma folate were not different between beer-drinking and alcohol-free beer-drinking periods. Conclusions: This study shows that moderate alcohol consumption does not affect plasma tHcy concentrations or S-adenosyl methionine/S-adenosyl homocysteine ratio. However, it does increase plasma vitamin B6 and decrease serum vitamin B12. Copyright © 2005 by the Research Society on Alcoholism. Subject HealthPhysiological SciencesB vitaminsHomocysteineModerate alcohol consumptionS-adenosyl methionine/S-adenosyl homocysteine ratioalcoholcyanocobalamincystathioninecysteinefolic acidhomocysteinemethioninepyridoxal 5 phosphatepyridoxines adenosylhomocysteines adenosylmethionineadultagedalcohol blood levelalcohol consumptionamino acid blood levelamino acid metabolismarticleblood analysisclinical articleclinical trialcontrolled clinical trialcontrolled studycrossover proceduredietfemalefolic acid blood levelhumankineticsmalepriority journalrandomized controlled trialvitamin blood levelAgedAmino Acids, SulfurBeerCentral Nervous System DepressantsCross-Over StudiesDietEthanolFemaleHomocysteineHumansKineticsMaleMiddle AgedS-AdenosylmethionineVitamin B Complex To reference this document use: http://resolver.tudelft.nl/uuid:c8340a39-8275-4f01-97d8-90a9220d9ab4 DOI https://doi.org/10.1097/01.alc.0000163507.76773.1a TNO identifier 238443 ISSN 0145-6008 Source Alcoholism: Clinical and Experimental Research, 29 (5), 739-745 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.